This report analyzes your genotyping data from 23andMe. and presents Polygenic Risk Scores (PRS) for 71 traits across 14 health categories. Each PRS reflects the cumulative effect of hundreds to thousands of common genetic variants associated with a trait in large population studies, primarily the UK Biobank.
What is a Polygenic Risk Score? A PRS is not a diagnosis. It quantifies statistical predisposition. Your genetic profile is one of many factors influencing health, alongside lifestyle, environment, and medical history. Most traits are only modestly influenced by genetics; a high PRS increases the statistical probability of a condition but does not predict with certainty that you will develop it.
How to read this report:
- Percentile — where your genetic score sits in the population. The 50th percentile is average; above 80th is considered elevated.
- Odds ratio (OR) — for disease traits, how your odds compare to the population average. An OR of 1.5 means roughly 50% higher odds than average.
- "About Average" — when the 95% confidence interval includes 1.0, the difference from average is not statistically meaningful and the result is labeled About Average.
- Estimated lifetime risk — for disease traits, an approximate lifetime probability derived from your odds ratio and UK Biobank population prevalence. This is a statistical estimate, not a clinical prediction.
- Top contributing variants — each score card has an expandable section showing the individual genetic variants that contribute most to your score. These are the variants with the largest effect on your personal result, but they are not necessarily causal. Polygenic scores combine hundreds to thousands of variants, each contributing a small amount. The listed variants simply had the largest individual weight in your calculation.
- Effect-size distribution — each score card also includes an expandable chart showing how the trait measurement or odds ratio varies across PRS percentile bins in the reference population. Your bin is highlighted. These charts help you understand the magnitude of the genetic effect: a steep curve means the score strongly differentiates risk across the population, while a flat curve means genetics plays a smaller role for that trait.
- Appearance & Body 4 scores
- Cardiovascular 9 scores
- Cancer 4 scores
- Metabolic & Hormonal 4 scores
- Body Composition 4 scores
- Musculoskeletal 4 scores
- Respiratory & Sleep 4 scores
- Neurological 3 scores
- Mental Health & Cognition 1 scores
- Immune & Autoimmune 4 scores
- Digestive Health 4 scores
- Blood & Hematology 11 scores
- Eye Health 2 scores
- Lifestyle 7 scores
- Important Disclaimers
- Methodology
- FAQ
These scores reflect your genetic predisposition toward each hair color category independently. A higher percentile indicates a stronger genetic tendency for that color.
Light brown hair effect-size distribution
Red hair effect-size distribution
Blonde hair effect-size distribution
Brown hair effect-size distribution
Black hair effect-size distribution
Dark brown hair effect-size distribution
Adult height is one of the most heritable human traits, with genetics explaining roughly 80% of the variation. Hundreds of genetic variants each make small contributions to your final height, alongside nutrition and health during childhood.
Your score for Height is in the top 20%, indicating an elevated genetic predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (5'7", 169.8 cm). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 3:185548683:G:A | rs720390 | 1/1 | 0.3944 | 2.00 | — | Intergenic | ↑ |
| 6:19839415:C:T | rs41271299 | 0/1 | 0.6870 | 1.00 | ID4 | Intronic | ↑ |
| 15:100692953:G:A | rs72755233 | 0|1 | -0.5392 | 1.00 | ADAMTS17 | Missense | ↓ |
| 4:18025484:G:A | rs2011603 | 1|1 | -0.2370 | 2.00 | LCORL | Upstream | ↓ |
| 11:75276178:A:C | rs606452 | 1/1 | -0.2352 | 2.00 | SERPINH1 | Intronic | ↓ |
| 15:67457698:A:G | rs35874463 | 0/1 | 0.4458 | 1.00 | SMAD3 | Missense | ↑ |
| 20:34025756:A:G | rs143384 | 0/1 | 0.4271 | 1.00 | GDF5 | 5-prime UTR | ↑ |
| 12:69827658:G:T | rs10748128 | 1/1 | 0.2053 | 2.00 | — | Intergenic | ↑ |
| 6:130349119:C:T | rs6569648 | 1/1 | -0.1934 | 2.00 | L3MBTL3 | Intronic | ↓ |
| 12:66359752:C:A | rs8756 | 1/1 | -0.1905 | 2.00 | HMGA2 | 3-prime UTR | ↓ |
BMI (body mass index) is a common measure of body size calculated from height and weight. While it does not distinguish between fat and muscle mass, it is a useful screening tool. Both genetics and lifestyle influence BMI.
Your score for BMI falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (28.0 kg/m²). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 16:53800954:T:C | rs1421085 | 1/0 | 0.3454 | 1.00 | FTO | Intronic | ↑ |
| 2:637830:A:G | rs13393304 | 1|1 | 0.1410 | 2.00 | — | Intergenic | ↑ |
| 3:49924940:T:C | rs1062633 | 1|1 | 0.1143 | 2.00 | MST1R | Missense | ↑ |
| 19:47569003:G:A | rs3810291 | 1/1 | 0.1136 | 2.00 | ZC3H4 | 3-prime UTR | ↑ |
| 16:4013467:C:T | rs2531995 | 1/1 | 0.1046 | 2.00 | ADCY9 | 3-prime UTR | ↑ |
| 4:100239319:T:C | rs1229984 | 1|1 | 0.0892 | 2.00 | ADH1B | Missense | ↑ |
| 11:27701365:G:A | rs10835211 | 1/1 | 0.0826 | 2.00 | BDNF | Intronic | ↑ |
| 2:622827:T:C | rs2867125 | 1/1 | 0.0765 | 2.00 | — | Intergenic | ↑ |
| 14:25930988:C:A | rs8015400 | 1|1 | 0.0706 | 2.00 | — | Intergenic | ↑ |
| 16:20370810:C:T | rs9652588 | 1|1 | -0.0702 | 2.00 | PDILT | Missense | ↓ |
Fluid intelligence is the ability to reason and solve novel problems independent of previously acquired knowledge. It tends to peak in early adulthood and gradually decline with age. It is moderately heritable and influenced by many genetic variants.
Your score for Fluid intelligence is near the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (7.27 score). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 6:98565211:C:T | rs1487445 | 1|1 | 0.0500 | 2.00 | RP11-436D23.1 | Intronic | ↑ |
| 12:108618630:C:T | rs3764002 | 1|1 | 0.0279 | 2.00 | WSCD2 | Missense | ↑ |
| 10:130107905:T:C | rs2254606 | 1/1 | -0.0277 | 2.00 | — | Intergenic | ↓ |
| 5:92528272:C:T | rs4285204 | 1|1 | -0.0268 | 2.00 | — | Regulatory | ↓ |
| 3:9389577:G:T | rs2728939 | 1|1 | -0.0260 | 2.00 | RP11-380O24.1 | Intronic | ↓ |
| 4:106196951:A:G | rs2454206 | 0/1 | -0.0505 | 1.00 | TET2 | Missense | ↓ |
| 13:106636056:C:T | rs2478292 | 1|1 | -0.0251 | 2.00 | — | Intergenic | ↓ |
| 6:11481086:G:A | rs34486680 | 1|1 | -0.0244 | 2.00 | RP11-716O23.1 | Intronic | ↓ |
| 1:41788265:G:A | rs12043581 | 1|0 | -0.0486 | 1.00 | — | Intergenic | ↓ |
| 10:114906714:G:A | rs290490 | 1|1 | 0.0238 | 2.00 | TCF7L2 | Intronic | ↑ |
Skin tanning ability reflects how your skin responds to UV radiation. People who burn easily and tan poorly have less protective melanin and higher risk of skin cancer. Variants in pigmentation genes like MC1R strongly influence this trait.
Your score for Ease of Skin Tanning is in the top 20%, indicating an elevated genetic predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 16:89986117:C:T | rs1805007 | 0/1 | 1.0449 | 1.00 | MC1R | Missense | ↑ |
| 15:28365618:A:G | rs12913832 | 1/1 | 0.3890 | 2.00 | HERC2 | Intronic | ↑ |
| 16:89985844:G:T | rs1805005 | 0/1 | 0.4156 | 1.00 | MC1R | Missense | ↑ |
| 11:89017961:G:A | rs1126809 | 1|0 | 0.2996 | 1.00 | TYR | Missense | ↑ |
| 9:16864521:C:T | rs2153271 | 1/1 | 0.1203 | 2.00 | BNC2 | Intronic | ↑ |
| 11:88911696:C:A | rs1042602 | 1/0 | 0.1579 | 1.00 | TYR | Missense | ↑ |
| 11:68855363:G:A | rs3829241 | 1|1 | 0.0604 | 2.00 | TPCN2 | Missense | ↑ |
| 1:66921933:G:A | rs1772131 | 1|1 | 0.0540 | 2.00 | — | Intergenic | ↑ |
| 20:32738612:C:T | rs1015362 | 0/1 | -0.1023 | 1.00 | — | Intergenic | ↓ |
| 8:116586460:C:T | rs3779881 | 1|1 | -0.0501 | 2.00 | TRPS1 | Intronic | ↓ |
Atrial fibrillation (AFib) is an irregular, often rapid heart rhythm originating in the upper chambers of the heart. It increases the risk of stroke, heart failure, and other cardiovascular complications. Risk rises with age and is partly genetic.
Your score for Atrial fibrillation falls in the bottom 20% of the population, suggesting a lower-than-average genetic predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 4:111718067:G:A | rs6843082 | 1/1 | -0.2890 | 2.00 | RP11-777N19.1 | Non-coding | ↓ |
| 12:114793240:C:T | rs883079 | 1/1 | 0.0964 | 2.00 | TBX5 | 3-prime UTR | ↑ |
| 4:111761487:T:C | rs3853445 | 1/0 | -0.1661 | 1.00 | — | Regulatory | ↓ |
| 16:73051620:C:T | rs2106261 | 0/1 | 0.1265 | 1.00 | ZFHX3 | Intronic | ↑ |
| 4:111580136:A:G | rs35323363 | 1|0 | -0.1213 | 1.00 | — | Intergenic | ↓ |
| 10:105299611:T:C | rs6584555 | 1|1 | 0.0493 | 2.00 | NEURL1 | Intronic | ↑ |
| 14:64680848:A:G | rs1152591 | 1|1 | -0.0451 | 2.00 | SYNE2 | Intronic | ↓ |
| 8:17796382:A:G | rs412750 | 1|1 | 0.0435 | 2.00 | PCM1 | Missense | ↑ |
| 11:20011445:T:C | rs10741807 | 1|1 | -0.0431 | 2.00 | NAV2 | Intronic | ↓ |
| 9:97509199:A:G | rs446540 | 1|1 | -0.0382 | 2.00 | C9orf3 | Intronic | ↓ |
Varicose veins are enlarged, twisted veins most commonly seen in the legs, caused by weakened valves that allow blood to pool. While often considered cosmetic, they can cause aching, swelling, and in severe cases skin ulcers. Family history is one of the strongest risk factors.
Your score for Varicose veins is in the top 20%, indicating an elevated genetic predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:10824329:T:C | rs6540950 | 1|1 | -0.0795 | 2.00 | CASZ1 | Intronic | ↓ |
| 19:49206674:G:A | rs601338 | 1/1 | 0.0463 | 2.00 | FUT2 | Loss of Function | ↑ |
| 12:48209165:G:T | rs11168250 | 1|1 | 0.0437 | 2.00 | HDAC7 | Intronic | ↑ |
| 5:158256118:A:G | rs11954193 | 1|1 | -0.0430 | 2.00 | EBF1 | Intronic | ↓ |
| 16:88804734:A:G | rs7184427 | 1|0 | -0.0832 | 1.00 | PIEZO1 | Missense | ↓ |
| 5:127347013:A:G | rs34145453 | 1|0 | 0.0725 | 1.00 | CTC-228N24.3 | Intronic | ↑ |
| 2:68385097:A:G | rs2044693 | 0|1 | 0.0696 | 1.00 | PNO1 | Missense | ↑ |
| 9:130673419:C:T | rs3780668 | 1|1 | -0.0328 | 2.00 | ST6GALNAC4 | Intronic | ↓ |
| 15:83539575:G:T | rs1256441 | 1|1 | 0.0314 | 2.00 | HOMER2 | Intronic | ↑ |
| 17:43470156:G:A | rs1230094 | 1/1 | 0.0299 | 2.00 | CTB-39G8.3 | Upstream | ↑ |
Resting heart rate is the number of times your heart beats per minute while at rest. A normal range is 60 to 100 bpm, with lower rates generally indicating better cardiovascular fitness. Both genetics and physical conditioning influence your resting rate.
Your score for Resting heart rate is above the population average, suggesting a higher-than-average predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (70.2 beats per minute). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 2:179839888:G:A | rs10497529 | 1/0 | 0.9538 | 1.00 | CCDC141 | Missense | ↑ |
| 6:122158270:G:A | rs12110693 | 1/0 | 0.8805 | 1.00 | — | Intergenic | ↑ |
| 14:23861811:A:G | rs365990 | 0/1 | 0.7229 | 1.00 | MYH6 | Missense | ↑ |
| 6:118667522:T:C | rs11153730 | 1/1 | -0.2759 | 2.00 | — | Intergenic | ↓ |
| 16:65279257:T:C | rs9921437 | 1|1 | -0.2566 | 2.00 | RP11-256I9.3 | Intronic | ↓ |
| 20:36841914:G:A | rs3746471 | 1|0 | -0.4405 | 1.00 | KIAA1755 | Missense | ↓ |
| 1:208024820:C:T | rs12731740 | 0/1 | 0.4260 | 1.00 | C1orf132 | Intronic | ↑ |
| 9:128319066:G:A | rs506874 | 1|1 | 0.2022 | 2.00 | MAPKAP1 | Intronic | ↑ |
| 11:128768938:C:T | rs2846700 | 1|1 | -0.1967 | 2.00 | KCNJ5 | Intronic | ↓ |
| 3:49054692:T:C | rs3087866 | 1|1 | 0.1869 | 2.00 | DALRD3 | Missense | ↑ |
Deep vein thrombosis (DVT) is a blood clot that forms in a deep vein, usually in the leg. If the clot breaks loose it can travel to the lungs (pulmonary embolism), which can be life-threatening. Genetic clotting factor variants like Factor V Leiden significantly increase risk.
Your score for Deep vein thrombosis falls somewhat below the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:169519049:T:C | rs6025 | 1/1 | -0.8206 | 2.00 | F5 | Missense | ↓ |
| 9:136143442:A:G | rs612169 | 1|0 | 0.1498 | 1.00 | ABO | Intronic | ↑ |
| 9:136155000:C:T | rs2129834802 | 0/1 | 0.1320 | 1.00 | ABO | Upstream | ↑ |
| 12:54952742:T:C | rs10876566 | 1|1 | -0.0438 | 2.00 | PDE1B | Intronic | ↓ |
| 4:187207381:C:T | rs2289252 | 0/1 | 0.0561 | 1.00 | F11-AS1 | Non-coding | ↑ |
| 19:10742170:A:G | rs2288904 | 1/1 | 0.0276 | 2.00 | SLC44A2 | Missense | ↑ |
| 4:187188094:T:G | rs4253399 | 1/0 | 0.0539 | 1.00 | F11 | Intronic | ↑ |
| 4:187158034:G:A | rs3733402 | 1|0 | 0.0484 | 1.00 | KLKB1 | Missense | ↑ |
| 8:128586999:T:C | rs7814563 | 1|1 | -0.0233 | 2.00 | — | Regulatory | ↓ |
| 18:11936967:C:T | rs644270 | 1|1 | 0.0233 | 2.00 | — | Intergenic | ↑ |
A heart attack (myocardial infarction) occurs when blood flow to part of the heart muscle is blocked, usually by a blood clot in a coronary artery. Family history is one of the strongest risk factors, alongside high cholesterol, blood pressure, smoking, and diabetes.
Your score for Heart attack falls somewhat below the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 12:111884608:T:C | rs3184504 | 1/0 | -0.0686 | 1.00 | SH2B3 | Missense | ↓ |
| 1:222923351:A:G | rs6683071 | 1/1 | 0.0333 | 2.00 | FAM177B | Missense | ↑ |
| 1:109822166:G:A | rs599839 | 1/1 | 0.0317 | 2.00 | CELSR2 | Downstream | ↑ |
| 17:66449122:G:A | rs883541 | 1/1 | 0.0283 | 2.00 | WIPI1 | Missense | ↑ |
| 9:22115959:A:G | rs2383207 | 0/1 | 0.0524 | 1.00 | CDKN2B-AS1 | Intronic | ↑ |
| 7:35291491:G:A | rs73099187 | 1|1 | -0.0244 | 2.00 | TBX20 | Intronic | ↓ |
| 1:222826481:G:A | rs2291832 | 1|1 | 0.0239 | 2.00 | MIA3 | Intronic | ↑ |
| 2:106823652:C:T | rs13006272 | 1|1 | -0.0227 | 2.00 | — | Intergenic | ↓ |
| 7:129663496:C:T | rs11556924 | 0/1 | -0.0401 | 1.00 | ZC3HC1 | Missense | ↓ |
| 2:196851911:G:A | rs10931715 | 1|1 | 0.0190 | 2.00 | DNAH7 | Missense | ↑ |
High cholesterol means elevated levels of cholesterol in the blood, particularly LDL ("bad") cholesterol. Over time this can lead to plaque buildup in arteries, increasing the risk of heart attack and stroke. Genetics and diet both play important roles.
Your score for High cholesterol is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 2:21294975:G:A | rs541041 | 1/1 | 0.0877 | 2.00 | — | Intergenic | ↑ |
| 19:45422946:A:G | rs4420638 | 0/1 | 0.1417 | 1.00 | APOC1 | Downstream | ↑ |
| 19:49206674:G:A | rs601338 | 1/1 | 0.0475 | 2.00 | FUT2 | Loss of Function | ↑ |
| 8:126507389:C:A | rs2954038 | 1/0 | -0.0857 | 1.00 | RP11-136O12.2 | Intronic | ↓ |
| 2:27730940:T:C | rs1260326 | 1/0 | -0.0830 | 1.00 | GCKR | Missense | ↓ |
| 2:21233972:T:C | rs533617 | 1/0 | -0.0761 | 1.00 | APOB | Missense | ↓ |
| 2:44074431:C:T | rs4245791 | 0/1 | -0.0761 | 1.00 | ABCG8 | Intronic | ↓ |
| 20:17844684:G:T | rs2618566 | 1|1 | -0.0348 | 2.00 | — | Regulatory | ↓ |
| 19:45395266:G:A | rs157580 | 1/1 | 0.0327 | 2.00 | TOMM40 | Intronic | ↑ |
| 2:21231524:G:A | rs676210 | 1/1 | -0.0292 | 2.00 | APOB | Missense | ↓ |
Essential hypertension is persistently elevated blood pressure with no identifiable underlying cause. It is the most common form of high blood pressure, affecting roughly one in three adults, and is a major risk factor for heart disease and stroke.
Your score for Essential hypertension falls somewhat below the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 19:49206674:G:A | rs601338 | 1/1 | 0.0367 | 2.00 | FUT2 | Loss of Function | ↑ |
| 5:32830521:T:C | rs1173727 | 1/1 | 0.0322 | 2.00 | — | Intergenic | ↑ |
| 1:18023690:A:G | rs2270976 | 1/1 | 0.0298 | 2.00 | ARHGEF10L | Missense | ↑ |
| 7:27245893:T:C | rs3735533 | 1|1 | 0.0284 | 2.00 | HOTTIP | Non-coding | ↑ |
| 11:123053078:T:C | rs7113140 | 1|1 | 0.0261 | 2.00 | CLMP | Intronic | ↑ |
| 1:10796866:T:C | rs880315 | 1/0 | 0.0516 | 1.00 | CASZ1 | Intronic | ↑ |
| 2:26932031:C:T | rs2586886 | 0|1 | -0.0509 | 1.00 | KCNK3 | Intronic | ↓ |
| 12:32704908:G:A | rs4635166 | 1|1 | 0.0234 | 2.00 | FGD4 | Intronic | ↑ |
| 10:115781547:T:C | rs2782981 | 1|1 | 0.0231 | 2.00 | — | Intergenic | ↑ |
| 6:127147704:C:T | rs9375459 | 0|1 | 0.0456 | 1.00 | — | Intergenic | ↑ |
Diastolic blood pressure is the pressure in your arteries between heartbeats, when the heart is resting. Persistently high diastolic pressure (above 80 mmHg) contributes to cardiovascular risk. Together with systolic pressure, it provides a complete picture of cardiovascular strain.
Your score for Diastolic Blood Pressure is near the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (82.6 mmHg). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 3:41996136:T:C | rs2272007 | 1/1 | -0.2138 | 2.00 | ULK4 | Missense | ↓ |
| 5:32830521:T:C | rs1173727 | 1/1 | 0.1912 | 2.00 | — | Intergenic | ↑ |
| 11:10673739:T:C | rs4909945 | 1/1 | -0.1698 | 2.00 | MRVI1 | Missense | ↓ |
| 12:111884608:T:C | rs3184504 | 1/0 | -0.3347 | 1.00 | SH2B3 | Missense | ↓ |
| 10:115781547:T:C | rs2782981 | 1|1 | 0.1552 | 2.00 | — | Intergenic | ↑ |
| 15:96637569:A:G | rs7174546 | 1|1 | -0.1271 | 2.00 | — | Intergenic | ↓ |
| 2:145634153:G:A | rs6738560 | 1|1 | -0.1212 | 2.00 | TEX41 | Intronic | ↓ |
| 7:27245893:T:C | rs3735533 | 1|1 | 0.1150 | 2.00 | HOTTIP | Non-coding | ↑ |
| 19:11526765:G:T | rs167479 | 1|0 | -0.2241 | 1.00 | RGL3 | Missense | ↓ |
| 19:45766729:G:A | rs7255933 | 1|1 | 0.1068 | 2.00 | MARK4 | Intronic | ↑ |
Systolic blood pressure is the pressure in your arteries when your heart beats. Persistently high readings (above 130 mmHg) increase the risk of heart attack, stroke, and kidney disease. Both genetics and lifestyle factors like diet and exercise play a role.
Your score for Systolic blood pressure is near the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (139.8 mmHg). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 5:32830521:T:C | rs1173727 | 1/1 | 0.4360 | 2.00 | — | Intergenic | ↑ |
| 4:100239319:T:C | rs1229984 | 1|1 | 0.4016 | 2.00 | ADH1B | Missense | ↑ |
| 10:102556175:A:G | rs7072737 | 1|1 | 0.3550 | 2.00 | PAX2 | Intronic | ↑ |
| 7:27220831:A:G | rs6461992 | 1|1 | 0.2716 | 2.00 | HOXA11-AS | Upstream | ↑ |
| 13:21562832:C:T | rs2770928 | 1|1 | -0.2263 | 2.00 | LATS2 | Missense | ↓ |
| 10:115781547:T:C | rs2782981 | 1|1 | 0.2126 | 2.00 | — | Intergenic | ↑ |
| 17:76799795:G:A | rs1057040 | 1|1 | -0.2118 | 2.00 | USP36 | Missense | ↓ |
| 19:11526765:G:T | rs167479 | 1|0 | -0.4137 | 1.00 | RGL3 | Missense | ↓ |
| 16:65279257:T:C | rs9921437 | 1|1 | 0.2043 | 2.00 | RP11-256I9.3 | Intronic | ↑ |
| 5:158296996:C:T | rs2072495 | 1|1 | 0.1921 | 2.00 | EBF1 | Intronic | ↑ |
Prostate cancer is the most common non-skin cancer in men. It usually grows slowly and many cases are detected through screening. Family history is a major risk factor: men with a first-degree relative diagnosed have roughly double the risk.
Your score for Prostate cancer falls somewhat below the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 8:128517573:A:G | rs4242382 | 1/1 | -0.1460 | 2.00 | — | Intergenic | ↓ |
| 8:128413305:G:T | rs6983267 | 0/1 | -0.1952 | 1.00 | CASC8 | Intronic | ↓ |
| 10:51549496:T:C | rs10993994 | 1/0 | -0.1611 | 1.00 | MSMB | Upstream | ↓ |
| 8:23526463:T:C | rs1512268 | 1/1 | -0.0799 | 2.00 | — | Intergenic | ↓ |
| 6:117130704:G:A | rs2274911 | 1|1 | 0.0792 | 2.00 | GPRC6A | Missense | ↑ |
| 19:51361757:T:C | rs17632542 | 1/0 | -0.1433 | 1.00 | KLK3 | Missense | ↓ |
| 11:68994497:T:G | rs7931342 | 1/1 | 0.0568 | 2.00 | — | Intergenic | ↑ |
| 8:128333180:C:T | rs622856 | 1|1 | -0.0566 | 2.00 | CASC8 | Intronic | ↓ |
| 17:69108753:G:T | rs1859962 | 0/1 | -0.0908 | 1.00 | CASC17 | Intronic | ↓ |
| 22:43500212:G:T | rs5759167 | 0/1 | -0.0877 | 1.00 | — | Regulatory | ↓ |
Melanoma is the most serious form of skin cancer, arising from the pigment-producing cells (melanocytes) in the skin. Fair skin, a history of sunburns, and many moles are risk factors. Genetics influence skin pigmentation, mole count, and DNA repair capacity.
Your score for Melanoma is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 16:89986117:C:T | rs1805007 | 0/1 | 0.2427 | 1.00 | MC1R | Missense | ↑ |
| 11:89017961:G:A | rs1126809 | 1|0 | 0.0862 | 1.00 | TYR | Missense | ↑ |
| 5:1315660:G:A | rs4975616 | 1/1 | -0.0285 | 2.00 | CLPTM1L | Downstream | ↓ |
| 3:183800463:G:A | rs7648737 | 1|1 | -0.0272 | 2.00 | RP11-778D9.9 | Loss of Function | ↓ |
| 9:21816758:G:A | rs7023954 | 0|1 | -0.0443 | 1.00 | MTAP | Missense | ↓ |
| 16:81242198:G:A | rs7499011 | 1|1 | 0.0213 | 2.00 | PKD1L2 | Loss of Function | ↑ |
| 15:59981515:A:G | rs3087328 | 1|1 | 0.0185 | 2.00 | BNIP2 | Missense | ↑ |
| 22:36122930:C:T | rs2076671 | 1|1 | -0.0175 | 2.00 | APOL5 | Missense | ↓ |
| 3:42735150:T:C | rs11079 | 1/0 | -0.0315 | 1.00 | HHATL | Missense | ↓ |
| 11:108175462:G:A | rs1801516 | 1/0 | -0.0313 | 1.00 | ATM | Missense | ↓ |
Breast cancer is the most commonly diagnosed cancer in women worldwide. While high-penetrance genes like BRCA1 and BRCA2 get the most attention, most genetic risk comes from the combined effect of many common variants, each contributing a small amount.
Your score for Breast cancer is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 16:52599188:C:T | rs4784227 | 0/1 | 0.1495 | 1.00 | CASC16 | Intronic | ↑ |
| 10:123346116:G:A | rs2981575 | 1/0 | -0.1150 | 1.00 | FGFR2 | Intronic | ↓ |
| 3:27368884:T:C | rs3920005 | 1|1 | -0.0572 | 2.00 | NEK10 | Intronic | ↓ |
| 10:123337335:A:G | rs2981579 | 0/1 | -0.0925 | 1.00 | FGFR2 | Intronic | ↓ |
| 8:128355618:A:G | rs13281615 | 1/1 | 0.0383 | 2.00 | CASC8 | Intronic | ↑ |
| 5:158296996:C:T | rs2072495 | 1|1 | -0.0382 | 2.00 | EBF1 | Intronic | ↓ |
| 16:53816275:C:A | rs8050136 | 1/0 | -0.0538 | 1.00 | FTO | Intronic | ↓ |
| 7:99474427:A:G | rs2572023 | 1/1 | -0.0246 | 2.00 | OR2AE1 | Missense | ↓ |
| 10:123095012:C:T | rs35098964 | 1|0 | -0.0472 | 1.00 | — | Intergenic | ↓ |
| 6:151936677:G:A | rs6929137 | 1/0 | 0.0466 | 1.00 | CCDC170 | Missense | ↑ |
Non-melanoma skin cancers, primarily basal cell carcinoma and squamous cell carcinoma, are the most common cancers overall. They are strongly linked to cumulative UV exposure and fair skin. While rarely fatal, they can cause significant tissue damage if untreated.
Your score for Non-melanoma skin cancer is near the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 16:89986117:C:T | rs1805007 | 0/1 | 0.1954 | 1.00 | MC1R | Missense | ↑ |
| 20:2290333:C:A | rs214803 | 1/0 | -0.1460 | 1.00 | TGM3 | Missense | ↓ |
| 10:8944052:A:G | rs76407406 | 1|0 | -0.1185 | 1.00 | RP11-428L9.1 | Intronic | ↓ |
| 2:202143928:T:C | rs10931936 | 1|1 | -0.0588 | 2.00 | CASP8 | Intronic | ↓ |
| 1:17722363:G:A | rs7538876 | 1/1 | 0.0552 | 2.00 | PADI6 | Intronic | ↑ |
| 5:1287194:G:A | rs2853677 | 1/1 | -0.0532 | 2.00 | TERT | Intronic | ↓ |
| 16:89985844:G:T | rs1805005 | 0/1 | 0.1031 | 1.00 | MC1R | Missense | ↑ |
| 11:89017961:G:A | rs1126809 | 1|0 | 0.0983 | 1.00 | TYR | Missense | ↑ |
| 9:16864521:C:T | rs2153271 | 1/1 | 0.0469 | 2.00 | BNC2 | Intronic | ↑ |
| 21:43086816:G:A | rs2850128 | 1|1 | -0.0417 | 2.00 | — | Intergenic | ↓ |
Gout is an intensely painful form of arthritis caused by the buildup of uric acid crystals in joints, most often the big toe. Genetics strongly influence uric acid levels, and flare-ups can be triggered by diet, alcohol, and dehydration.
Your score for Gout is in the top 5%, indicating a substantially elevated predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 4:89052323:G:T | rs2231142 | 0/1 | 0.5653 | 1.00 | ABCG2 | Missense | ↑ |
| 4:89083666:T:C | rs3114020 | 1|1 | 0.0847 | 2.00 | ABCG2 | Intronic | ↑ |
| 10:61465838:A:G | rs1171619 | 1|1 | 0.0705 | 2.00 | SLC16A9 | Intronic | ↑ |
| 2:27730940:T:C | rs1260326 | 1/0 | -0.1360 | 1.00 | GCKR | Missense | ↓ |
| 6:25813150:G:A | rs1165196 | 1/0 | 0.1248 | 1.00 | SLC17A1 | Missense | ↑ |
| 11:64334114:C:T | rs2078267 | 0/1 | -0.1232 | 1.00 | SLC22A11 | Non-coding | ↓ |
| 1:145723645:T:C | rs1967017 | 1/1 | -0.0594 | 2.00 | PDZK1 | Upstream | ↓ |
| 2:170010985:T:C | rs2075252 | 1/1 | -0.0557 | 2.00 | LRP2 | Missense | ↓ |
| 11:66328095:T:C | rs1815739 | 1/1 | 0.0470 | 2.00 | ACTN3 | Loss of Function | ↑ |
| 11:65552154:C:T | rs948493 | 1|1 | 0.0428 | 2.00 | AP5B1 | Upstream | ↑ |
Hypothyroidism occurs when the thyroid gland does not produce enough thyroid hormone, leading to fatigue, weight gain, cold sensitivity, and slowed metabolism. The most common cause is Hashimoto's thyroiditis, an autoimmune condition with a strong genetic component.
Your score for Hypothyroidism is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:114377568:A:G | rs2476601 | 0|1 | -0.3535 | 1.00 | PTPN22 | Missense | ↓ |
| 12:111884608:T:C | rs3184504 | 1/0 | -0.1994 | 1.00 | SH2B3 | Missense | ↓ |
| 2:191964633:T:G | rs7574865 | 1/1 | -0.0914 | 2.00 | STAT4 | Intronic | ↓ |
| 9:100546600:C:T | rs925489 | 0/1 | 0.1763 | 1.00 | — | Intergenic | ↑ |
| 13:24782560:G:A | rs7323885 | 1|1 | 0.0696 | 2.00 | SPATA13 | Intronic | ↑ |
| 2:204732714:A:G | rs231775 | 0/1 | 0.1045 | 1.00 | CTLA4 | Missense | ↑ |
| 5:133419283:C:T | rs244672 | 1|1 | -0.0517 | 2.00 | CTB-113I20.1 | Upstream | ↓ |
| 1:198869514:T:C | rs10800598 | 1|1 | -0.0452 | 2.00 | MIR181A1HG | Non-coding | ↓ |
| 6:90976768:G:A | rs72928038 | 1/0 | 0.0878 | 1.00 | BACH2 | Intronic | ↑ |
| 11:95311422:T:C | rs4409785 | 1/0 | 0.0866 | 1.00 | — | Intergenic | ↑ |
Type 1 diabetes is an autoimmune condition in which the immune system destroys insulin-producing cells in the pancreas. It usually appears in childhood or adolescence and requires lifelong insulin therapy. The HLA gene region on chromosome 6 is the strongest genetic risk factor.
Your score for Type 1 diabetes is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 6:32626272:C:A | rs9273363 | 1/0 | 0.5582 | 1.00 | HLA-DQB1-AS1 | Upstream | ↑ |
| 11:2181073:G:A | rs3842752 | 0|1 | -0.1958 | 1.00 | INS | Missense | ↓ |
| 6:32406342:A:C | rs3129871 | 0/1 | 0.1593 | 1.00 | HLA-DRA | Upstream | ↑ |
| 1:114377568:A:G | rs2476601 | 0|1 | -0.1547 | 1.00 | PTPN22 | Missense | ↓ |
| 6:32626302:T:G | rs9273364 | 0|1 | 0.1385 | 1.00 | HLA-DQB1-AS1 | Upstream | ↑ |
| 6:64694354:C:T | rs4710457 | 1|1 | 0.0688 | 2.00 | EYS | Missense | ↑ |
| 6:32411035:A:C | rs8084 | 0/1 | 0.1355 | 1.00 | HLA-DRA | Loss of Function | ↑ |
| 8:142458053:A:G | rs6578185 | 1|0 | 0.1008 | 1.00 | MROH5 | Loss of Function | ↑ |
| 20:31826027:T:C | rs6059183 | 0|1 | 0.0584 | 1.00 | BPIFA1 | Splice Region | ↑ |
| 6:31602967:G:A | rs1046089 | 1/0 | 0.0563 | 1.00 | PRRC2A | Missense | ↑ |
Type 2 diabetes occurs when the body becomes resistant to insulin or the pancreas cannot produce enough. It is the most common form of diabetes, closely linked to obesity, physical inactivity, and family history. Early detection and lifestyle changes can significantly reduce risk.
Your score for Type 2 diabetes falls somewhat below the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 5:169310213:A:C | rs17646221 | 1|1 | 0.0474 | 2.00 | FAM196B | Missense | ↑ |
| 22:50752150:C:T | rs68178377 | 1|1 | 0.0376 | 2.00 | DENND6B | Missense | ↑ |
| 11:64124515:T:C | rs612448 | 1|1 | -0.0338 | 2.00 | CCDC88B | Missense | ↓ |
| 9:22137685:T:G | rs7018475 | 1/1 | 0.0297 | 2.00 | — | Intergenic | ↑ |
| 12:6948468:T:C | rs1129649 | 1|1 | 0.0275 | 2.00 | LEPREL2 | Loss of Function | ↑ |
| 4:37910836:G:A | rs2925951 | 1|1 | -0.0274 | 2.00 | TBC1D1 | Intronic | ↓ |
| 3:183800463:G:A | rs7648737 | 1|1 | -0.0242 | 2.00 | RP11-778D9.9 | Loss of Function | ↓ |
| 9:22132076:A:G | rs2383208 | 0/1 | -0.0452 | 1.00 | — | Intergenic | ↓ |
| 11:32293377:C:A | rs7105928 | 1|1 | -0.0197 | 2.00 | RP1-65P5.1 | Intronic | ↓ |
| 11:8264900:A:G | rs437976 | 1/1 | -0.0196 | 2.00 | LMO1 | Intronic | ↓ |
Fat-free mass includes muscle, bone, water, and organs. Essentially, it is everything in your body that is not fat. Higher fat-free mass is generally associated with greater physical strength and a higher resting metabolic rate.
Your score for Fat-free mass is in the top 20%, indicating an elevated genetic predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile. Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 8:120596023:A:G | rs10283100 | 1|1 | 0.2351 | 2.00 | ENPP2 | Missense | ↑ |
| 3:185548683:G:A | rs720390 | 1/1 | 0.1781 | 2.00 | — | Intergenic | ↑ |
| 16:53800954:T:C | rs1421085 | 1/0 | 0.3546 | 1.00 | FTO | Intronic | ↑ |
| 6:19839415:C:T | rs41271299 | 0/1 | 0.2962 | 1.00 | ID4 | Intronic | ↑ |
| 2:622827:T:C | rs2867125 | 1/1 | 0.1466 | 2.00 | — | Intergenic | ↑ |
| 4:18025484:G:A | rs2011603 | 1|1 | -0.1400 | 2.00 | LCORL | Upstream | ↓ |
| 1:176792249:A:G | rs1325598 | 1|1 | 0.1330 | 2.00 | PAPPA2 | Intronic | ↑ |
| 6:130349119:C:T | rs6569648 | 1/1 | -0.1281 | 2.00 | L3MBTL3 | Intronic | ↓ |
| 3:141102833:G:A | rs6763931 | 1/0 | 0.2546 | 1.00 | ZBTB38 | Intronic | ↑ |
| 19:47569003:G:A | rs3810291 | 1/1 | 0.1212 | 2.00 | ZC3H4 | 3-prime UTR | ↑ |
Body fat percentage measures the proportion of your weight made up of fat tissue. Genetics influence where and how much fat your body stores. It is considered a more precise indicator of metabolic health than BMI alone.
Your score for Body fat percentage falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (31.2 percent). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 16:53800954:T:C | rs1421085 | 1/0 | 0.3026 | 1.00 | FTO | Intronic | ↑ |
| 12:108618630:C:T | rs3764002 | 1|1 | -0.1375 | 2.00 | WSCD2 | Missense | ↓ |
| 2:637830:A:G | rs13393304 | 1|1 | 0.1305 | 2.00 | — | Intergenic | ↑ |
| 16:4013467:C:T | rs2531995 | 1/1 | 0.1080 | 2.00 | ADCY9 | 3-prime UTR | ↑ |
| 14:29685328:G:A | rs974471 | 1|1 | 0.1024 | 2.00 | — | Regulatory | ↑ |
| 19:47569003:G:A | rs3810291 | 1/1 | 0.0907 | 2.00 | ZC3H4 | 3-prime UTR | ↑ |
| 11:27701365:G:A | rs10835211 | 1/1 | 0.0899 | 2.00 | BDNF | Intronic | ↑ |
| 13:58265596:G:A | rs9597588 | 1|1 | -0.0887 | 2.00 | PCDH17 | Intronic | ↓ |
| 1:29475648:T:G | rs2230679 | 1|1 | 0.0856 | 2.00 | SRSF4 | Missense | ↑ |
| 19:33953743:A:G | rs6510386 | 1|1 | 0.0855 | 2.00 | PEPD | Intronic | ↑ |
Trunk fat refers to fat stored around the abdomen and internal organs (visceral fat). Higher trunk fat is associated with greater risk of cardiovascular disease, type 2 diabetes, and metabolic syndrome, regardless of overall weight.
Your score for Trunk fat percentage falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile. Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 16:53800954:T:C | rs1421085 | 1/0 | 0.2824 | 1.00 | FTO | Intronic | ↑ |
| 12:108618630:C:T | rs3764002 | 1|1 | -0.1389 | 2.00 | WSCD2 | Missense | ↓ |
| 2:637830:A:G | rs13393304 | 1|1 | 0.1297 | 2.00 | — | Intergenic | ↑ |
| 14:29685328:G:A | rs974471 | 1|1 | 0.1174 | 2.00 | — | Regulatory | ↑ |
| 16:4013467:C:T | rs2531995 | 1/1 | 0.1155 | 2.00 | ADCY9 | 3-prime UTR | ↑ |
| 19:33899065:G:A | rs731839 | 1/1 | 0.1022 | 2.00 | PEPD | Intronic | ↑ |
| 11:27701365:G:A | rs10835211 | 1/1 | 0.0975 | 2.00 | BDNF | Intronic | ↑ |
| 12:123112806:G:A | rs6489159 | 1|1 | 0.0920 | 2.00 | HCAR1 | Intronic | ↑ |
| 19:47569003:G:A | rs3810291 | 1/1 | 0.0918 | 2.00 | ZC3H4 | 3-prime UTR | ↑ |
| 1:29475648:T:G | rs2230679 | 1|1 | 0.0906 | 2.00 | SRSF4 | Missense | ↑ |
Waist circumference is a measure of abdominal fat and is considered a better predictor of metabolic health risk than BMI alone. Excess abdominal fat is associated with increased risk of type 2 diabetes, heart disease, and metabolic syndrome.
Your score for Waist circumference is near the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (3'0", 91.4 cm). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 16:53800954:T:C | rs1421085 | 1/0 | 0.7170 | 1.00 | FTO | Intronic | ↑ |
| 2:637830:A:G | rs13393304 | 1|1 | 0.2615 | 2.00 | — | Intergenic | ↑ |
| 11:27701365:G:A | rs10835211 | 1/1 | 0.2284 | 2.00 | BDNF | Intronic | ↑ |
| 4:100239319:T:C | rs1229984 | 1|1 | 0.2172 | 2.00 | ADH1B | Missense | ↑ |
| 19:47569003:G:A | rs3810291 | 1/1 | 0.2108 | 2.00 | ZC3H4 | 3-prime UTR | ↑ |
| 16:4013467:C:T | rs2531995 | 1/1 | 0.2095 | 2.00 | ADCY9 | 3-prime UTR | ↑ |
| 2:622827:T:C | rs2867125 | 1/1 | 0.2072 | 2.00 | — | Intergenic | ↑ |
| 16:20370810:C:T | rs9652588 | 1|1 | -0.1744 | 2.00 | PDILT | Missense | ↓ |
| 3:49924940:T:C | rs1062633 | 1|1 | 0.1618 | 2.00 | MST1R | Missense | ↑ |
| 2:76554776:G:T | rs10167686 | 1/1 | -0.1606 | 2.00 | — | Intergenic | ↓ |
Hand grip strength is a simple but powerful measure of overall muscular strength and health. Lower grip strength has been linked to higher risk of cardiovascular disease, disability, and mortality. Genetics, physical activity, and nutrition all influence it.
Your score for Hand grip strength is in the top 20%, indicating an elevated genetic predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (32.3 kilograms). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:176792249:A:G | rs1325598 | 1|1 | 0.1395 | 2.00 | PAPPA2 | Intronic | ↑ |
| 15:74336633:T:C | rs5742915 | 1/1 | 0.1124 | 2.00 | PML | Missense | ↑ |
| 1:41502680:C:A | rs1740610 | 1|1 | -0.1035 | 2.00 | SCMH1 | Intronic | ↓ |
| 5:130766662:T:C | rs1291602 | 1|1 | 0.0984 | 2.00 | RAPGEF6 | Missense | ↑ |
| 20:34025756:A:G | rs143384 | 0/1 | 0.1563 | 1.00 | GDF5 | 5-prime UTR | ↑ |
| 10:70332580:A:G | rs10823229 | 1|1 | 0.0745 | 2.00 | TET1 | Missense | ↑ |
| 2:224992906:C:T | rs988321 | 1|1 | -0.0715 | 2.00 | — | Regulatory | ↓ |
| 12:14993439:C:T | rs11276 | 0|1 | -0.1397 | 1.00 | ART4 | Missense | ↓ |
| 6:130374102:C:A | rs9388768 | 1|1 | -0.0697 | 2.00 | L3MBTL3 | Missense | ↓ |
| 17:43216281:C:T | rs4986172 | 1/1 | -0.0683 | 2.00 | ACBD4 | Intronic | ↓ |
Bone mineral density (BMD) measures how dense and strong your bones are. Lower BMD means bones are more fragile and more likely to fracture. Genetics account for a large share of BMD variation, with diet, exercise, and hormones also contributing.
Your score for Heel bone mineral density falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (1.55 g/cm²). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 7:38110626:T:C | rs1524068 | 1|1 | 0.0053 | 2.00 | — | Intergenic | ↑ |
| 3:41123735:C:T | rs10490823 | 1/1 | 0.0050 | 2.00 | — | Intergenic | ↑ |
| 11:27325462:G:A | rs10835157 | 1|1 | -0.0048 | 2.00 | — | Intergenic | ↓ |
| 2:202832130:T:C | rs10931982 | 1|1 | 0.0048 | 2.00 | — | Intergenic | ↑ |
| 20:39832628:T:C | rs17265513 | 1/1 | -0.0048 | 2.00 | ZHX3 | Missense | ↓ |
| 7:96133531:T:C | rs7781370 | 1/1 | 0.0047 | 2.00 | SHFM1 | Intronic | ↑ |
| 6:152009638:A:G | rs2941740 | 1/1 | 0.0042 | 2.00 | ESR1 | Intronic | ↑ |
| 1:220197625:G:T | rs2230301 | 1|1 | -0.0041 | 2.00 | EPRS | Missense | ↓ |
| 11:46898771:T:C | rs6485702 | 1|1 | -0.0041 | 2.00 | LRP4 | Missense | ↓ |
| 10:54411308:C:A | rs10762857 | 1|1 | 0.0037 | 2.00 | RP11-556E13.1 | Intronic | ↑ |
Osteoarthritis is the most common form of arthritis, caused by the gradual breakdown of cartilage that cushions the joints. It most often affects the knees, hips, and hands. Aging, joint injury, obesity, and genetics all contribute to risk.
Your score for Osteoarthritis is near the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:103444679:T:G | rs11164649 | 1|1 | 0.0165 | 2.00 | COL11A1 | Intronic | ↑ |
| 3:49924940:T:C | rs1062633 | 1|1 | 0.0150 | 2.00 | MST1R | Missense | ↑ |
| 2:70703847:C:A | rs958685 | 1|0 | -0.0270 | 1.00 | TGFA | Intronic | ↓ |
| 12:69619392:A:G | rs6581887 | 1|1 | -0.0109 | 2.00 | RP11-324P9.1 | Downstream | ↓ |
| 10:131704434:C:T | rs4751145 | 1|1 | 0.0101 | 2.00 | EBF3 | Intronic | ↑ |
| 10:51827934:G:A | rs55875820 | 0|1 | 0.0201 | 1.00 | FAM21A | Missense | ↑ |
| 19:3093163:T:C | rs4806907 | 1/1 | -0.0092 | 2.00 | GNA11 | Upstream | ↓ |
| 8:4755088:T:C | rs7000541 | 1|1 | -0.0092 | 2.00 | CSMD1 | Intronic | ↓ |
| 7:6656897:A:G | rs1806552 | 1|1 | 0.0089 | 2.00 | ZNF853 | Missense | ↑ |
| 6:55142337:A:G | rs2653349 | 1/1 | -0.0087 | 2.00 | HCRTR2 | Missense | ↓ |
Osteoporosis is a condition in which bones become weak and brittle, greatly increasing fracture risk. It is most common in postmenopausal women and older adults. Family history, low calcium intake, and physical inactivity are important risk factors.
Your score for Osteoporosis is near the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 3:41123735:C:T | rs10490823 | 1/1 | -0.0391 | 2.00 | — | Intergenic | ↓ |
| 11:46898771:T:C | rs6485702 | 1|1 | 0.0306 | 2.00 | LRP4 | Missense | ↑ |
| 6:152009638:A:G | rs2941740 | 1/1 | -0.0299 | 2.00 | ESR1 | Intronic | ↓ |
| 12:53662624:C:A | rs6580942 | 1|1 | 0.0284 | 2.00 | ESPL1 | Missense | ↑ |
| 18:51820805:G:A | rs8305 | 1/1 | 0.0265 | 2.00 | POLI | Missense | ↑ |
| 1:68603586:C:T | rs983034 | 0/1 | 0.0520 | 1.00 | WLS | Missense | ↑ |
| 3:46187707:G:A | rs4683184 | 1|1 | -0.0243 | 2.00 | FLT1P1 | Upstream | ↓ |
| 3:49538799:T:C | rs11130199 | 1|1 | -0.0239 | 2.00 | DAG1 | Intronic | ↓ |
| 4:88775243:T:C | rs1471403 | 1/0 | 0.0456 | 1.00 | — | Intergenic | ↑ |
| 7:38136277:T:C | rs1524058 | 1/0 | -0.0454 | 1.00 | — | Intergenic | ↓ |
Habitual snoring occurs when airflow through the nose and throat is partially obstructed during sleep. It can be a sign of obstructive sleep apnea, a condition linked to cardiovascular disease and daytime fatigue. Anatomy, weight, and genetics all play a role.
Your score for Snoring falls in the bottom 20% of the population, suggesting a lower-than-average genetic predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 10:9061370:C:T | rs2589559 | 1|1 | -0.0226 | 2.00 | — | Intergenic | ↓ |
| 11:8484089:C:T | rs10769908 | 1|1 | -0.0190 | 2.00 | STK33 | Intronic | ↓ |
| 3:55710455:C:T | rs815416 | 1|1 | -0.0169 | 2.00 | ERC2 | Intronic | ↓ |
| 13:40739333:G:A | rs7339301 | 1|1 | -0.0145 | 2.00 | — | Intergenic | ↓ |
| 7:77043863:A:G | rs6465633 | 1/1 | 0.0139 | 2.00 | GSAP | Intronic | ↑ |
| 4:25408838:G:A | rs34811474 | 0|1 | -0.0274 | 1.00 | ANAPC4 | Missense | ↓ |
| 1:34750936:T:C | rs771390 | 1|1 | 0.0136 | 2.00 | — | Intergenic | ↑ |
| 2:156751921:T:C | rs1520339 | 1|1 | 0.0136 | 2.00 | — | Intergenic | ↑ |
| 6:116446576:A:G | rs1064583 | 1/1 | -0.0133 | 2.00 | COL10A1 | Missense | ↓ |
| 13:69482984:G:A | rs9541621 | 1|1 | 0.0130 | 2.00 | — | Intergenic | ↑ |
FEV1 (forced expiratory volume in one second) measures how much air you can exhale in one second and is a key indicator of lung health. Lower values can indicate obstructive conditions like asthma or COPD. Genetics, smoking history, and environmental exposures all influence lung function.
Your score for Lung function is above the population average, suggesting a higher-than-average predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (1.76). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 12:96249476:A:C | rs4762631 | 1|1 | -0.0016 | 2.00 | RP11-536G4.2 | Intronic | ↓ |
| 1:218521609:G:A | rs2799098 | 1|1 | -0.0013 | 2.00 | TGFB2 | Intronic | ↓ |
| 16:75415341:T:C | rs1549306 | 1|1 | -0.0012 | 2.00 | CFDP1 | Intronic | ↓ |
| 4:89860847:C:T | rs2464523 | 1/1 | -0.0012 | 2.00 | FAM13A | Intronic | ↓ |
| 1:92077097:G:A | rs1192415 | 1/0 | 0.0024 | 1.00 | — | Regulatory | ↑ |
| 22:18472430:A:G | rs393719 | 1|1 | 0.0012 | 2.00 | MICAL3 | Intronic | ↑ |
| 1:239881926:A:G | rs891700 | 1|1 | -0.0010 | 2.00 | CHRM3-AS2 | Intronic | ↓ |
| 10:89827275:C:T | rs1855972 | 1|1 | 0.0010 | 2.00 | — | Intergenic | ↑ |
| 2:239876527:T:C | rs62191107 | 1|0 | 0.0020 | 1.00 | — | Intergenic | ↑ |
| 1:92373747:A:G | rs12141128 | 1|1 | 0.0010 | 2.00 | TGFBR3 | Upstream | ↑ |
COPD (chronic obstructive pulmonary disease) is a progressive lung condition that makes it increasingly hard to breathe. Smoking is the leading cause, but genetics (most notably alpha-1 antitrypsin deficiency) can increase susceptibility even in non-smokers.
Your score for COPD is near the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 15:78882925:G:A | rs16969968 | 1/0 | 0.0621 | 1.00 | CHRNA5 | Missense | ↑ |
| 12:68125847:A:C | rs1904566 | 1|1 | -0.0244 | 2.00 | RP11-43N5.1 | Upstream | ↓ |
| 4:145480780:A:G | rs1828591 | 1|0 | -0.0471 | 1.00 | — | Intergenic | ↓ |
| 11:1267325:T:C | rs55813014 | 0|1 | -0.0401 | 1.00 | MUC5B | Missense | ↓ |
| 3:108634973:C:A | rs10933973 | 1|1 | 0.0191 | 2.00 | GUCA1C | Loss of Function | ↑ |
| 22:17412806:C:T | rs5992590 | 1|1 | 0.0178 | 2.00 | IGKV1OR22-1 | Downstream | ↑ |
| 6:152005534:C:T | rs851995 | 1/1 | 0.0170 | 2.00 | ESR1 | Intronic | ↑ |
| 11:30848413:C:T | rs1448941 | 1|1 | -0.0166 | 2.00 | DCDC1 | Downstream | ↓ |
| 8:86253982:C:T | rs1496532 | 1/1 | 0.0163 | 2.00 | CA1 | Loss of Function | ↑ |
| 3:136574501:A:G | rs1052618 | 1|1 | 0.0161 | 2.00 | SLC35G2 | Missense | ↑ |
Asthma is a chronic condition in which the airways become inflamed and narrowed, causing wheezing, shortness of breath, and coughing. It often begins in childhood and frequently co-occurs with allergies and eczema. Genetics and environmental exposures both contribute.
Your score for Asthma is near the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 11:76291154:G:A | rs61893460 | 1|1 | 0.0782 | 2.00 | — | Intergenic | ↑ |
| 9:6072597:T:C | rs343476 | 1|1 | 0.0661 | 2.00 | — | Intergenic | ↑ |
| 17:38064469:T:C | rs11078928 | 1|0 | -0.0823 | 1.00 | GSDMB | Loss of Function | ↓ |
| 5:110401872:T:C | rs1837253 | 1/0 | 0.0784 | 1.00 | TSLP | Upstream | ↑ |
| 5:110406742:C:T | rs3806933 | 1/1 | -0.0360 | 2.00 | TSLP | 5-prime UTR | ↓ |
| 16:11541896:G:A | rs4238608 | 1/1 | -0.0350 | 2.00 | CTD-3088G3.8 | Missense | ↓ |
| 10:9049253:C:T | rs12413578 | 0/1 | -0.0691 | 1.00 | — | Intergenic | ↓ |
| 5:131901225:A:G | rs2244012 | 0/1 | 0.0666 | 1.00 | RAD50 | Intronic | ↑ |
| 14:69254191:C:T | rs4902647 | 1|1 | -0.0319 | 2.00 | ZFP36L1 | Downstream | ↓ |
| 4:38799710:T:C | rs4833095 | 1/0 | -0.0629 | 1.00 | TLR1 | Missense | ↓ |
Alzheimer's disease is the most common cause of dementia, characterized by progressive memory loss, confusion, and cognitive decline. The APOE gene is the strongest common genetic risk factor, with the e4 variant significantly increasing risk. Age is the single biggest non-genetic factor.
Your score for Alzheimer's disease is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (9)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 19:45422946:A:G | rs4420638 | 0/1 | 0.6437 | 1.00 | APOC1 | Downstream | ↑ |
| 19:45410002:G:A | rs769449 | 1/0 | 0.1896 | 1.00 | APOE | Non-coding | ↑ |
| 19:45395714:T:C | rs157581 | 1/0 | 0.1232 | 1.00 | TOMM40 | Synonymous | ↑ |
| 8:86253982:C:T | rs1496532 | 1/1 | -0.0459 | 2.00 | CA1 | Loss of Function | ↓ |
| 19:58003580:A:G | rs2074071 | 1|1 | -0.0303 | 2.00 | ZNF419 | Loss of Function | ↓ |
| 8:146067054:G:A | rs1735169 | 1|1 | -0.0106 | 2.00 | ZNF7 | Missense | ↓ |
| 17:3953102:A:G | rs781852 | 0|1 | 0.0151 | 1.00 | ZZEF1 | Missense | ↑ |
| 12:49308284:A:G | rs10747556 | 0/1 | 0.0017 | 1.00 | CCDC65 | Missense | ↑ |
| 3:171395468:A:G | rs2124147 | 1|0 | 0.0015 | 1.00 | PLD1 | Missense | ↑ |
Multiple sclerosis (MS) is an autoimmune disease in which the immune system attacks the myelin sheath that protects nerve fibers, disrupting communication between the brain and body. The HLA gene region is the strongest genetic risk factor, and vitamin D levels and viral infections also play a role.
Your score for Multiple sclerosis is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 6:32411035:A:C | rs8084 | 0/1 | -0.0672 | 1.00 | HLA-DRA | Loss of Function | ↓ |
| 14:69254191:C:T | rs4902647 | 1|1 | -0.0207 | 2.00 | ZFP36L1 | Downstream | ↓ |
| 4:103557077:G:A | rs2866413 | 1/0 | 0.0368 | 1.00 | MANBA | Missense | ↑ |
| 19:8808373:G:T | rs4804079 | 1/1 | 0.0166 | 2.00 | ACTL9 | Missense | ↑ |
| 7:123773562:C:T | rs12672951 | 1|1 | -0.0155 | 2.00 | RP5-921G16.1 | Intronic | ↓ |
| 11:64597506:T:C | rs3741395 | 0|1 | -0.0286 | 1.00 | CDC42BPG | Missense | ↓ |
| 8:145059425:T:C | rs11136344 | 1/0 | 0.0268 | 1.00 | PARP10 | Missense | ↑ |
| 6:12124855:G:A | rs2228213 | 1/0 | -0.0204 | 1.00 | HIVEP1 | Missense | ↓ |
| 8:145058986:A:G | rs11136343 | 0|1 | 0.0201 | 1.00 | PARP10 | Missense | ↑ |
| 12:12062539:C:T | rs3983843 | 1|0 | -0.0118 | 1.00 | — | Intergenic | ↓ |
Migraine is a neurological condition causing recurrent episodes of intense, often one-sided headache, frequently accompanied by nausea, light sensitivity, and visual disturbances (aura). It affects about 15% of adults and has a strong genetic component.
Your score for Migraine is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 6:97058553:A:G | rs2273621 | 0/1 | 0.0459 | 1.00 | FHL5 | Missense | ↑ |
| 12:57527283:T:C | rs11172113 | 1/0 | -0.0381 | 1.00 | LRP1 | Intronic | ↓ |
| 2:211540507:C:A | rs1047891 | 1/0 | 0.0287 | 1.00 | CPS1 | Missense | ↑ |
| 11:3249984:C:T | rs12295710 | 1|0 | 0.0177 | 1.00 | MRGPRE | Missense | ↑ |
| 12:57525756:G:A | rs4759275 | 0|1 | -0.0168 | 1.00 | LRP1 | Intronic | ↓ |
| 9:119252629:A:G | rs6478241 | 1/1 | -0.0083 | 2.00 | ASTN2 | Intronic | ↓ |
| 5:74965122:G:A | rs34358 | 0|1 | -0.0154 | 1.00 | ANKDD1B | Loss of Function | ↓ |
| 1:3083712:T:C | rs2651899 | 1/0 | 0.0122 | 1.00 | PRDM16 | Intronic | ↑ |
| 11:10673739:T:C | rs4909945 | 1/1 | 0.0051 | 2.00 | MRVI1 | Missense | ↑ |
| 2:234825093:T:C | rs10166942 | 1/0 | -0.0024 | 1.00 | TRPM8 | Upstream | ↓ |
This trait captures a person's self-reported tendency to worry or feel anxious. While not a clinical diagnosis, chronic anxiety can affect quality of life and is associated with higher risk of depression and cardiovascular disease. Both genetic and environmental factors contribute.
Your score for Worrier/anxious feelings is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 2:10178236:A:G | rs4396680 | 1|1 | -0.0249 | 2.00 | KLF11 | Upstream | ↓ |
| 11:31812582:C:T | rs2071754 | 1|1 | -0.0222 | 2.00 | PAX6 | Non-coding | ↓ |
| 16:59463985:A:G | rs2048319 | 1|1 | -0.0217 | 2.00 | — | Intergenic | ↓ |
| 12:108618630:C:T | rs3764002 | 1|1 | 0.0204 | 2.00 | WSCD2 | Missense | ↑ |
| 3:50369546:C:A | rs2073498 | 1|1 | 0.0183 | 2.00 | RASSF1 | Missense | ↑ |
| 7:561838:T:C | rs62433354 | 1|1 | -0.0173 | 2.00 | AC147651.3 | Non-coding | ↓ |
| 11:27701365:G:A | rs10835211 | 1/1 | -0.0171 | 2.00 | BDNF | Intronic | ↓ |
| 19:9490814:C:T | rs2217652 | 1/1 | 0.0168 | 2.00 | ZNF177 | Missense | ↑ |
| 6:12029416:T:G | rs2327505 | 1|1 | 0.0166 | 2.00 | HIVEP1 | Intronic | ↑ |
| 17:8243785:A:G | rs12936935 | 1|1 | -0.0164 | 2.00 | ODF4 | Missense | ↓ |
Eczema (atopic dermatitis) is a chronic inflammatory skin condition causing itchy, inflamed patches. It often begins in childhood and can persist into adulthood, frequently co-occurring with asthma and hay fever. Skin-barrier gene variants like those in FLG are important risk factors.
Your score for Eczema/dermatitis is in the top 5%, indicating a substantially elevated predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:152176769:A:G | rs61814928 | 1/1 | 0.0460 | 2.00 | FLG-AS1 | Intronic | ↑ |
| 11:76291154:G:A | rs61893460 | 1|1 | 0.0438 | 2.00 | — | Intergenic | ↑ |
| 1:152193286:G:T | rs7545406 | 1|1 | 0.0302 | 2.00 | HRNR | Missense | ↑ |
| 5:131995964:A:G | rs20541 | 0/1 | -0.0540 | 1.00 | IL13 | Missense | ↓ |
| 5:172725336:G:A | rs11744669 | 1|1 | -0.0266 | 2.00 | — | Intergenic | ↓ |
| 10:64376558:T:C | rs10822037 | 1|1 | 0.0246 | 2.00 | ZNF365 | Intronic | ↑ |
| 1:154426970:A:C | rs2228145 | 1|0 | 0.0474 | 1.00 | IL6R | Missense | ↑ |
| 1:152308971:C:T | rs61816764 | 1/1 | 0.0214 | 2.00 | FLG-AS1 | Intronic | ↑ |
| 11:76299194:G:T | rs2155219 | 1/1 | 0.0211 | 2.00 | RP11-672A2.7 | Upstream | ↑ |
| 4:122683007:G:A | rs4370153 | 1|1 | 0.0202 | 2.00 | TMEM155 | Missense | ↑ |
Psoriasis is a chronic autoimmune condition that causes skin cells to multiply too quickly, leading to thick, red, scaly patches. It can also affect the joints (psoriatic arthritis). The HLA-C gene region is the strongest genetic risk factor.
Your score for Psoriasis falls in the bottom 20% of the population, suggesting a lower-than-average genetic predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 5:158826357:A:G | rs918519 | 1/1 | -0.0906 | 2.00 | — | Intergenic | ↓ |
| 5:158787385:G:A | rs6556412 | 1/0 | -0.0946 | 1.00 | AC008697.1 | Intronic | ↓ |
| 5:96124330:T:C | rs30187 | 1/1 | -0.0394 | 2.00 | ERAP1 | Missense | ↓ |
| 19:10475652:C:A | rs2304256 | 1/0 | -0.0780 | 1.00 | TYK2 | Missense | ↓ |
| 17:41167957:C:A | rs455055 | 1|1 | -0.0317 | 2.00 | VAT1 | Loss of Function | ↓ |
| 1:152551276:A:G | rs4112788 | 1/1 | 0.0310 | 2.00 | LCE3D | Downstream | ↑ |
| 1:152552285:C:A | rs512208 | 1|1 | 0.0279 | 2.00 | LCE3D | Missense | ↑ |
| 12:111884608:T:C | rs3184504 | 1/0 | -0.0537 | 1.00 | SH2B3 | Missense | ↓ |
| 11:128379964:A:G | rs7951925 | 0/1 | -0.0477 | 1.00 | ETS1 | Intronic | ↓ |
| 1:197812669:G:A | rs6692930 | 1|1 | -0.0233 | 2.00 | — | Intergenic | ↓ |
Rheumatoid arthritis (RA) is a chronic autoimmune disease in which the immune system mistakenly attacks the joints, causing pain, swelling, and eventual joint damage. It most commonly begins in middle age and is two to three times more common in women.
Your score for Rheumatoid arthritis falls somewhat below the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:114377568:A:G | rs2476601 | 0|1 | -0.0799 | 1.00 | PTPN22 | Missense | ↓ |
| 7:128578301:G:T | rs2004640 | 0|1 | 0.0407 | 1.00 | IRF5 | Loss of Function | ↑ |
| 11:131097789:G:T | rs1113927 | 1|1 | 0.0201 | 2.00 | — | Intergenic | ↑ |
| 4:983060:T:C | rs3796622 | 1|1 | 0.0198 | 2.00 | SLC26A1 | Missense | ↑ |
| 6:32406342:A:C | rs3129871 | 0/1 | 0.0370 | 1.00 | HLA-DRA | Upstream | ↑ |
| 5:55444683:G:A | rs7731626 | 1/0 | -0.0323 | 1.00 | ANKRD55 | Intronic | ↓ |
| 5:34542217:A:G | rs10941200 | 1|1 | -0.0135 | 2.00 | — | Intergenic | ↓ |
| 2:202006096:G:A | rs10190751 | 1/0 | 0.0265 | 1.00 | CFLAR | Loss of Function | ↑ |
| 17:2268311:G:A | rs2248821 | 1|0 | 0.0224 | 1.00 | SGSM2 | Missense | ↑ |
| 1:20442054:T:C | rs584367 | 0|1 | 0.0207 | 1.00 | PLA2G2D | Missense | ↑ |
Hay fever (allergic rhinitis) is an immune overreaction to airborne allergens like pollen, dust mites, or pet dander, causing sneezing, congestion, and itchy eyes. It is part of the "atopic triad" along with asthma and eczema, and tends to run in families.
Your score for Hayfever/allergic rhinitis falls somewhat below the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 11:76291154:G:A | rs61893460 | 1|1 | 0.0316 | 2.00 | — | Intergenic | ↑ |
| 4:38799710:T:C | rs4833095 | 1/0 | -0.0475 | 1.00 | TLR1 | Missense | ↓ |
| 1:167432949:T:C | rs1773542 | 1|1 | -0.0227 | 2.00 | CD247 | Intronic | ↓ |
| 15:91009484:G:A | rs2074585 | 1|1 | -0.0210 | 2.00 | IQGAP1 | Splice polypyrimidine tract variant | ↓ |
| 6:32337686:A:G | rs3129941 | 0/1 | -0.0416 | 1.00 | C6orf10 | Missense | ↓ |
| 7:99270539:C:T | rs776746 | 0/1 | 0.0401 | 1.00 | CYP3A5 | Loss of Function | ↑ |
| 5:110401872:T:C | rs1837253 | 1/0 | 0.0401 | 1.00 | TSLP | Upstream | ↑ |
| 1:85547945:T:C | rs7534574 | 1|1 | -0.0167 | 2.00 | WDR63 | Intronic | ↓ |
| 2:8438693:C:T | rs346835 | 0|1 | -0.0276 | 1.00 | LINC00299 | Intronic | ↓ |
| 9:6192796:T:C | rs2095044 | 0|1 | -0.0255 | 1.00 | RP11-575C20.1 | Upstream | ↓ |
Inflammatory bowel disease (IBD) is a group of chronic conditions, primarily Crohn's disease and ulcerative colitis, involving inflammation of the digestive tract. Symptoms include abdominal pain, diarrhea, and fatigue. Over 200 genetic loci have been linked to IBD risk.
Your score for Inflammatory bowel disease is in the top 5%, indicating a substantially elevated predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:67675516:C:T | rs11805303 | 1/1 | 0.0862 | 2.00 | IL23R | Intronic | ↑ |
| 1:20171860:G:A | rs6426833 | 1/1 | 0.0399 | 2.00 | — | Regulatory | ↑ |
| 21:40465534:G:A | rs2836878 | 1/0 | -0.0732 | 1.00 | — | Intergenic | ↓ |
| 1:161479745:A:G | rs1801274 | 0/1 | -0.0674 | 1.00 | FCGR2A | Missense | ↓ |
| 5:131676320:C:T | rs1050152 | 0/1 | 0.0651 | 1.00 | SLC22A4 | Missense | ↑ |
| 1:206939904:G:A | rs3024505 | 1/0 | 0.0591 | 1.00 | IL10 | Downstream | ↑ |
| 10:64415184:A:G | rs7076156 | 0/1 | 0.0519 | 1.00 | ZNF365 | Missense | ↑ |
| 17:38064469:T:C | rs11078928 | 1|0 | 0.0477 | 1.00 | GSDMB | Loss of Function | ↑ |
| 6:32626272:C:A | rs9273363 | 1/0 | -0.0445 | 1.00 | HLA-DQB1-AS1 | Upstream | ↓ |
| 5:10752315:C:T | rs267939 | 1|1 | -0.0202 | 2.00 | DAP | Intronic | ↓ |
Ulcerative colitis is a type of inflammatory bowel disease that specifically affects the colon and rectum, causing continuous inflammation of the inner lining. Symptoms include bloody diarrhea, abdominal cramps, and urgency. It shares genetic risk factors with other autoimmune conditions.
Your score for Ulcerative colitis is in the top 20%, indicating an elevated genetic predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:67670213:G:A | rs1004819 | 1/1 | 0.0722 | 2.00 | C1orf141 | Intronic | ↑ |
| 21:40465534:G:A | rs2836878 | 1/0 | -0.0932 | 1.00 | — | Intergenic | ↓ |
| 1:161479745:A:G | rs1801274 | 0/1 | -0.0927 | 1.00 | FCGR2A | Missense | ↓ |
| 17:27959903:G:A | rs2289629 | 1/1 | 0.0434 | 2.00 | SSH2 | Missense | ↑ |
| 1:20171860:G:A | rs6426833 | 1/1 | 0.0430 | 2.00 | — | Regulatory | ↑ |
| 1:151761172:A:G | rs12756855 | 1|1 | 0.0293 | 2.00 | TDRKH | Intronic | ↑ |
| 1:20131771:C:T | rs2314757 | 1|0 | -0.0544 | 1.00 | — | Intergenic | ↓ |
| 5:10752315:C:T | rs267939 | 1|1 | -0.0261 | 2.00 | DAP | Intronic | ↓ |
| 22:50435480:A:G | rs5771069 | 1/1 | 0.0236 | 2.00 | IL17REL | Missense | ↑ |
| 20:43065028:A:C | rs6017342 | 0/1 | 0.0433 | 1.00 | RP5-1013A22.5 | Downstream | ↑ |
Crohn's disease is a type of inflammatory bowel disease that can affect any part of the digestive tract, from mouth to anus. It causes chronic inflammation leading to abdominal pain, diarrhea, and malnutrition. Variants in the NOD2 gene were among the first genetic risk factors discovered.
Your score for Crohn's disease is in the top 20%, indicating an elevated genetic predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:67694202:A:G | rs2201841 | 1/1 | 0.0563 | 2.00 | IL23R | Intronic | ↑ |
| 2:234183368:A:G | rs2241880 | 1/1 | 0.0400 | 2.00 | ATG16L1 | Missense | ↑ |
| 9:96209943:T:C | rs10821128 | 1|0 | -0.0717 | 1.00 | FAM120AOS | Missense | ↓ |
| 1:67675516:C:T | rs11805303 | 1/1 | 0.0356 | 2.00 | IL23R | Intronic | ↑ |
| 5:40437948:C:T | rs9292777 | 0/1 | 0.0663 | 1.00 | — | Regulatory | ↑ |
| 4:41015899:C:T | rs4861358 | 1|1 | 0.0327 | 2.00 | APBB2 | Missense | ↑ |
| 20:4705718:C:T | rs2245220 | 1/1 | 0.0318 | 2.00 | PRND | Missense | ↑ |
| 7:48128850:G:A | rs3763505 | 1|0 | -0.0593 | 1.00 | UPP1 | Loss of Function | ↓ |
| 1:206943968:C:A | rs3024493 | 1/0 | 0.0591 | 1.00 | IL10 | Intronic | ↑ |
| 6:165798894:C:T | rs220807 | 1|1 | 0.0240 | 2.00 | PDE10A | Intronic | ↑ |
Gallstones are hardened deposits of bile that form in the gallbladder. They can cause severe abdominal pain when they block bile ducts. Risk factors include obesity, rapid weight loss, female sex, and genetics, particularly variants in the ABCG8 cholesterol transporter gene.
Your score for Gallstones falls in the bottom 20% of the population, suggesting a lower-than-average genetic predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 19:49206674:G:A | rs601338 | 1/1 | 0.0812 | 2.00 | FUT2 | Loss of Function | ↑ |
| 2:44074431:C:T | rs4245791 | 0/1 | 0.1451 | 1.00 | ABCG8 | Intronic | ↑ |
| 7:87106365:G:A | rs4148805 | 0|1 | -0.0933 | 1.00 | ABCB4 | Splice Region | ↓ |
| 19:48384749:G:A | rs10426201 | 1|1 | 0.0448 | 2.00 | SULT2A1 | Intronic | ↑ |
| 4:151199080:G:A | rs2290846 | 1|0 | 0.0855 | 1.00 | LRBA | Missense | ↑ |
| 3:149225903:A:G | rs6779678 | 1/1 | -0.0409 | 2.00 | TM4SF4 | Downstream | ↓ |
| 8:59388565:T:C | rs2081687 | 1/0 | -0.0794 | 1.00 | — | Intergenic | ↓ |
| 2:44001139:C:T | rs17031488 | 0|1 | -0.0626 | 1.00 | DYNC2LI1 | Upstream | ↓ |
| 12:108618630:C:T | rs3764002 | 1|1 | -0.0313 | 2.00 | WSCD2 | Missense | ↓ |
| 22:40654276:T:C | rs12628051 | 1/1 | 0.0255 | 2.00 | TNRC6B | Intronic | ↑ |
Platelets are small blood cells that help your body form clots to stop bleeding. A normal count ranges from about 150,000 to 400,000 per microliter. Counts that are too low increase bleeding risk, while counts that are too high can promote unwanted clotting.
Your score for Platelet count falls in the bottom 20% of the population, suggesting a lower-than-average genetic predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (255.6 cells per microliter). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:171949750:T:C | rs10914144 | 1|1 | -4.2711 | 2.00 | DNM3 | Intronic | ↓ |
| 12:111884608:T:C | rs3184504 | 1/0 | -7.6314 | 1.00 | SH2B3 | Missense | ↓ |
| 3:56849749:T:C | rs1354034 | 1/0 | 7.3695 | 1.00 | ARHGEF3 | Intronic | ↑ |
| 2:31464829:A:G | rs647316 | 1/1 | 3.5688 | 2.00 | EHD3 | Intronic | ↑ |
| 3:184090266:C:T | rs6141 | 1/1 | 2.9281 | 2.00 | THPO | 3-prime UTR | ↑ |
| 13:95898207:A:G | rs4148441 | 1/1 | 2.4019 | 2.00 | ABCC4 | Intronic | ↑ |
| 15:63341996:T:C | rs11071720 | 1/1 | 2.3174 | 2.00 | TPM1 | Intronic | ↑ |
| 20:30294682:T:C | rs80054178 | 1/0 | 4.5583 | 1.00 | BCL2L1 | Intronic | ↑ |
| 1:205237137:T:C | rs1668871 | 1/1 | 2.2740 | 2.00 | TMCC2 | Intronic | ↑ |
| 9:4763176:T:C | rs385893 | 1/0 | 4.0686 | 1.00 | — | Regulatory | ↑ |
Eosinophils are white blood cells involved in fighting parasitic infections and mediating allergic responses. Elevated counts (eosinophilia) are commonly seen in allergies, asthma, and eczema. Genetic variants influence baseline eosinophil levels independent of active disease.
Your score for Eosinophil count is in the top 20%, indicating an elevated genetic predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (1.18 cells/µL). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 12:111884608:T:C | rs3184504 | 1/0 | -0.0099 | 1.00 | SH2B3 | Missense | ↓ |
| 9:6193455:C:A | rs2381416 | 1/0 | -0.0075 | 1.00 | RP11-575C20.1 | Upstream | ↓ |
| 5:131901225:A:G | rs2244012 | 0/1 | 0.0070 | 1.00 | RAD50 | Intronic | ↑ |
| 7:75442723:G:A | rs11465293 | 1/0 | -0.0061 | 1.00 | CCL24 | Missense | ↓ |
| 10:28793239:A:G | rs2998285 | 1/1 | 0.0030 | 2.00 | — | Intergenic | ↑ |
| 1:9713500:G:A | rs4240896 | 1|1 | -0.0022 | 2.00 | C1orf200 | 3-prime UTR | ↓ |
| 7:92408370:C:T | rs445 | 0/1 | -0.0045 | 1.00 | CDK6 | Intronic | ↓ |
| 15:80191343:G:A | rs7257 | 1|1 | 0.0022 | 2.00 | ST20 | Missense | ↑ |
| 1:42365548:C:T | rs783625 | 1|1 | 0.0022 | 2.00 | HIVEP3 | Intronic | ↑ |
| 13:41188292:A:G | rs3900833 | 1|1 | 0.0022 | 2.00 | FOXO1 | Intronic | ↑ |
Basophils are the rarest type of white blood cell, making up less than 1% of circulating leukocytes. They play a role in allergic reactions and inflammation by releasing histamine and other chemicals. Elevated counts can be seen in allergic conditions and some blood disorders.
Your score for Basophil count falls in the bottom 20% of the population, suggesting a lower-than-average genetic predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (1.03 cells/µL). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:236108446:C:T | rs6662383 | 1|1 | 0.0028 | 2.00 | RP5-940F7.2 | Upstream | ↑ |
| 7:92408370:C:T | rs445 | 0/1 | -0.0025 | 1.00 | CDK6 | Intronic | ↓ |
| 3:46250652:C:T | rs3181077 | 1|1 | -0.0010 | 2.00 | CCR3 | Intronic | ↓ |
| 15:91009484:G:A | rs2074585 | 1|1 | -0.0009 | 2.00 | IQGAP1 | Splice polypyrimidine tract variant | ↓ |
| 8:22974450:T:C | rs9644063 | 1|1 | -0.0008 | 2.00 | TNFRSF10C | Missense | ↓ |
| 19:33754548:C:T | rs78744187 | 1|0 | -0.0011 | 1.00 | — | Intergenic | ↓ |
| 18:61377579:A:C | rs1395268 | 1/1 | -0.0005 | 2.00 | SERPINB11 | Missense | ↓ |
| 18:51820805:G:A | rs8305 | 1/1 | 0.0005 | 2.00 | POLI | Missense | ↑ |
| 7:45009341:A:G | rs3735485 | 1/1 | 0.0005 | 2.00 | MYO1G | Missense | ↑ |
| 3:128338953:T:C | rs1127030 | 1|1 | 0.0005 | 2.00 | RPN1 | 3-prime UTR | ↑ |
Hemoglobin is the protein inside red blood cells that carries oxygen. Low hemoglobin (anemia) causes fatigue, shortness of breath, and pallor. Iron deficiency is the most common cause worldwide, but genetics also influence baseline hemoglobin levels.
Your score for Hemoglobin is above the population average, suggesting a higher-than-average predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (15.2 g/dL). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 10:71093392:C:T | rs16926246 | 0/1 | 0.0956 | 1.00 | HK1 | Intronic | ↑ |
| 12:48512285:C:A | rs4760682 | 1|1 | -0.0348 | 2.00 | PFKM | Missense | ↓ |
| 12:111884608:T:C | rs3184504 | 1/0 | -0.0507 | 1.00 | SH2B3 | Missense | ↓ |
| 17:59456589:C:T | rs9895661 | 1/1 | -0.0247 | 2.00 | BCAS3 | Non-coding | ↓ |
| 2:46353166:A:G | rs10495928 | 0/1 | -0.0472 | 1.00 | PRKCE | Intronic | ↓ |
| 22:37509965:A:C | rs228929 | 1|1 | -0.0192 | 2.00 | TMPRSS6 | Upstream | ↓ |
| 1:231488524:C:T | rs2437150 | 1|1 | 0.0184 | 2.00 | SPRTN | Missense | ↑ |
| 9:136149399:G:A | rs1834956251 | 1/0 | -0.0361 | 1.00 | ABO | Intronic | ↓ |
| 9:130622946:T:C | rs4837197 | 1|1 | -0.0178 | 2.00 | — | Intergenic | ↓ |
| 14:64723525:G:A | rs12435857 | 1/1 | -0.0165 | 2.00 | ESR2 | Intronic | ↓ |
Red blood cells carry oxygen from the lungs to every tissue in the body. A low count (anemia) can cause fatigue and weakness, while a high count can thicken the blood and increase clotting risk. Genetics, altitude, and nutritional status all influence your count.
Your score for Red Blood Cell Count is above the population average, suggesting a higher-than-average predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (5.51 million cells/µL). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 19:33754548:C:T | rs78744187 | 1|0 | 0.0300 | 1.00 | — | Intergenic | ↑ |
| 6:139840693:A:C | rs592423 | 1|1 | 0.0119 | 2.00 | — | Regulatory | ↑ |
| 13:76075597:A:G | rs7318786 | 1|1 | -0.0119 | 2.00 | — | Intergenic | ↓ |
| 7:50428428:C:A | rs12718597 | 1/1 | -0.0108 | 2.00 | IKZF1 | Intronic | ↓ |
| 10:71093392:C:T | rs16926246 | 0/1 | 0.0196 | 1.00 | HK1 | Intronic | ↑ |
| 12:121162854:T:G | rs2948149 | 1|1 | 0.0094 | 2.00 | RP11-173P15.5 | Upstream | ↑ |
| 1:118154575:T:C | rs67224956 | 1|1 | 0.0092 | 2.00 | FAM46C | Intronic | ↑ |
| 1:231488524:C:T | rs2437150 | 1|1 | 0.0089 | 2.00 | SPRTN | Missense | ↑ |
| 12:4330215:C:T | rs4573764 | 0|1 | -0.0165 | 1.00 | — | Intergenic | ↓ |
| 12:48512285:C:A | rs4760682 | 1|1 | -0.0082 | 2.00 | PFKM | Missense | ↓ |
White blood cells (leukocytes) are the frontline of your immune system, defending against infections and foreign substances. Your baseline count is partly genetic. Persistently elevated counts can signal chronic inflammation, while low counts may indicate immune vulnerability.
Your score for White Blood Cell Count falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (7.96 cells per microliter). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 7:92408370:C:T | rs445 | 0/1 | -0.1157 | 1.00 | CDK6 | Intronic | ↓ |
| 19:45766729:G:A | rs7255933 | 1|1 | -0.0538 | 2.00 | MARK4 | Intronic | ↓ |
| 7:45009341:A:G | rs3735485 | 1/1 | 0.0522 | 2.00 | MYO1G | Missense | ↑ |
| 12:111884608:T:C | rs3184504 | 1/0 | -0.0999 | 1.00 | SH2B3 | Missense | ↓ |
| 1:236108446:C:T | rs6662383 | 1|1 | -0.0495 | 2.00 | RP5-940F7.2 | Upstream | ↓ |
| 7:28715056:A:G | rs16874653 | 1/1 | 0.0491 | 2.00 | CREB5 | Intronic | ↑ |
| 7:28279243:G:A | rs4722771 | 1/1 | 0.0456 | 2.00 | JAZF1-AS1 | Intronic | ↑ |
| 2:182313246:C:T | rs4667283 | 1|1 | 0.0415 | 2.00 | — | Intergenic | ↑ |
| 5:71741381:A:G | rs7729012 | 1|1 | -0.0400 | 2.00 | ZNF366 | Intronic | ↓ |
| 10:28793239:A:G | rs2998285 | 1/1 | 0.0393 | 2.00 | — | Intergenic | ↑ |
Neutrophils are the most abundant type of white blood cell and are the first responders to bacterial infections. A high count often indicates active infection or inflammation, while a persistently low count (neutropenia) can increase susceptibility to infections.
Your score for Neutrophil Count falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (5.25 cells/μL). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 7:92408370:C:T | rs445 | 0/1 | -0.0987 | 1.00 | CDK6 | Intronic | ↓ |
| 7:28279243:G:A | rs4722771 | 1/1 | 0.0461 | 2.00 | JAZF1-AS1 | Intronic | ↑ |
| 7:28715056:A:G | rs16874653 | 1/1 | 0.0438 | 2.00 | CREB5 | Intronic | ↑ |
| 19:45766729:G:A | rs7255933 | 1|1 | -0.0433 | 2.00 | MARK4 | Intronic | ↓ |
| 1:236108446:C:T | rs6662383 | 1|1 | -0.0393 | 2.00 | RP5-940F7.2 | Upstream | ↓ |
| 5:71741381:A:G | rs7729012 | 1|1 | -0.0323 | 2.00 | ZNF366 | Intronic | ↓ |
| 10:99097191:G:A | rs4917766 | 1/1 | 0.0304 | 2.00 | RP11-452K12.4 | Intronic | ↑ |
| 10:28793239:A:G | rs2998285 | 1/1 | 0.0301 | 2.00 | — | Intergenic | ↑ |
| 7:45009341:A:G | rs3735485 | 1/1 | 0.0286 | 2.00 | MYO1G | Missense | ↑ |
| 1:56905342:G:T | rs6588629 | 1|1 | 0.0275 | 2.00 | — | Intergenic | ↑ |
Lymphocytes are a major type of white blood cell central to the adaptive immune system, including T cells and B cells. They are essential for fighting viral infections and producing antibodies. Your baseline count is partly determined by genetics.
Your score for Lymphocyte count is above the population average, suggesting a higher-than-average predisposition.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (2.95 cells/μL). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 12:111884608:T:C | rs3184504 | 1/0 | -0.0435 | 1.00 | SH2B3 | Missense | ↓ |
| 7:45009341:A:G | rs3735485 | 1/1 | 0.0177 | 2.00 | MYO1G | Missense | ↑ |
| 19:16495774:A:C | rs2290669 | 0|1 | -0.0271 | 1.00 | EPS15L1 | Intronic | ↓ |
| 17:72700943:A:G | rs35489971 | 1|1 | 0.0127 | 2.00 | CD300LF | Missense | ↑ |
| 6:24806594:C:T | rs9358799 | 1|1 | -0.0124 | 2.00 | FAM65B | Loss of Function | ↓ |
| 4:38366090:T:C | rs13133642 | 1|1 | 0.0118 | 2.00 | RP11-83C7.1 | Upstream | ↑ |
| 1:160793560:A:G | rs509749 | 1|1 | 0.0113 | 2.00 | LY9 | Missense | ↑ |
| 1:114377568:A:G | rs2476601 | 0|1 | 0.0212 | 1.00 | PTPN22 | Missense | ↑ |
| 2:181899515:G:A | rs10187842 | 1|1 | 0.0103 | 2.00 | UBE2E3 | Intronic | ↑ |
| 9:86617265:A:G | rs1982151 | 1|1 | 0.0097 | 2.00 | RMI1 | Missense | ↑ |
Monocytes are white blood cells critical for immune surveillance. They circulate in the blood before migrating into tissues where they become macrophages, engulfing pathogens and dead cells. Chronically elevated levels can indicate systemic inflammation or infection.
Your score for Monocyte count falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (1.48 cells/uL). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 2:182313246:C:T | rs4667283 | 1|1 | 0.0171 | 2.00 | — | Intergenic | ↑ |
| 1:236108446:C:T | rs6662383 | 1|1 | -0.0081 | 2.00 | RP5-940F7.2 | Upstream | ↓ |
| 13:28624294:G:A | rs1933437 | 1/1 | 0.0073 | 2.00 | FLT3 | Missense | ↑ |
| 14:103844898:T:C | rs11621300 | 1|1 | 0.0072 | 2.00 | RP11-600F24.1 | Upstream | ↑ |
| 3:128310589:G:T | rs4286447 | 1|1 | 0.0069 | 2.00 | — | Intergenic | ↑ |
| 19:45766729:G:A | rs7255933 | 1|1 | -0.0060 | 2.00 | MARK4 | Intronic | ↓ |
| 15:64601979:G:A | rs11071790 | 1|1 | 0.0051 | 2.00 | CSNK1G1 | Intronic | ↑ |
| 16:85966548:A:G | rs76121846 | 1|0 | 0.0102 | 1.00 | RP11-542M13.3 | Downstream | ↑ |
| 5:149498151:G:A | rs246394 | 1|1 | -0.0051 | 2.00 | PDGFRB | Intronic | ↓ |
| 7:92408370:C:T | rs445 | 0/1 | -0.0102 | 1.00 | CDK6 | Intronic | ↓ |
Mean platelet volume (MPV) measures the average size of platelets in your blood. Larger platelets are generally more active in clotting. Elevated MPV has been associated with increased risk of cardiovascular events, while low MPV can occur in certain bone marrow conditions.
Your score for Mean Platelet Volume is near the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (10.3 fL). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:171949750:T:C | rs10914144 | 1|1 | 0.1681 | 2.00 | DNM3 | Intronic | ↑ |
| 3:56849749:T:C | rs1354034 | 1/0 | -0.2268 | 1.00 | ARHGEF3 | Intronic | ↓ |
| 12:122341560:A:G | rs58379261 | 1|1 | -0.1056 | 2.00 | PSMD9 | Intronic | ↓ |
| 1:205237137:T:C | rs1668871 | 1/1 | -0.0840 | 2.00 | TMCC2 | Intronic | ↓ |
| 2:31464829:A:G | rs647316 | 1/1 | -0.0784 | 2.00 | EHD3 | Intronic | ↓ |
| 12:51681903:T:C | rs7954976 | 1/1 | 0.0729 | 2.00 | BIN2 | Missense | ↑ |
| 12:122295335:T:C | rs1154510 | 1/1 | 0.0719 | 2.00 | HPD | Missense | ↑ |
| 19:55536595:G:A | rs1613662 | 1/1 | 0.0634 | 2.00 | GP6 | Missense | ↑ |
| 15:63341996:T:C | rs11071720 | 1/1 | -0.0620 | 2.00 | TPM1 | Intronic | ↓ |
| 1:171892085:G:A | rs2093184 | 1|1 | -0.0579 | 2.00 | DNM3 | Intronic | ↓ |
Mean corpuscular volume (MCV) measures the average size of your red blood cells. Small red blood cells (low MCV) can indicate iron deficiency, while large cells (high MCV) may suggest vitamin B12 or folate deficiency. Genetics also naturally influence MCV.
Your score for Mean Corpuscular Volume is near the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (92.2 fL). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 6:139840693:A:C | rs592423 | 1|1 | -0.2994 | 2.00 | — | Regulatory | ↓ |
| 7:50428428:C:A | rs12718597 | 1/1 | 0.2247 | 2.00 | IKZF1 | Intronic | ↑ |
| 19:33754548:C:T | rs78744187 | 1|0 | -0.3869 | 1.00 | — | Intergenic | ↓ |
| 12:121162854:T:G | rs2948149 | 1|1 | -0.1899 | 2.00 | RP11-173P15.5 | Upstream | ↓ |
| 13:76075597:A:G | rs7318786 | 1|1 | 0.1825 | 2.00 | — | Intergenic | ↑ |
| 22:37509965:A:C | rs228929 | 1|1 | -0.1699 | 2.00 | TMPRSS6 | Upstream | ↓ |
| 1:118154575:T:C | rs67224956 | 1|1 | -0.1490 | 2.00 | FAM46C | Intronic | ↓ |
| 6:139838419:C:A | rs628751 | 1/1 | -0.1327 | 2.00 | — | Intergenic | ↓ |
| 19:13024250:A:C | rs741702 | 1/1 | -0.1230 | 2.00 | GCDH | Intronic | ↓ |
| 22:37462926:G:A | rs2235321 | 1/1 | 0.1198 | 2.00 | TMPRSS6 | Synonymous | ↑ |
Glaucoma is a group of eye conditions that damage the optic nerve, usually due to elevated pressure inside the eye. It is a leading cause of irreversible blindness worldwide. Early stages often have no symptoms, making regular eye exams important for detection.
Your score for Glaucoma is near the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:165687205:G:A | rs4656461 | 1/1 | -0.1646 | 2.00 | — | Regulatory | ↓ |
| 4:7863618:A:G | rs4552460 | 1/1 | -0.0672 | 2.00 | AFAP1 | Intronic | ↓ |
| 9:107699196:G:T | rs2437819 | 1|1 | -0.0534 | 2.00 | — | Intergenic | ↓ |
| 9:22029445:G:A | rs10965215 | 1|0 | 0.0973 | 1.00 | CDKN2B-AS1 | Non-coding | ↑ |
| 17:10031090:C:T | rs12150284 | 0|1 | -0.0907 | 1.00 | GAS7 | Intronic | ↓ |
| 17:40146970:G:A | rs6503679 | 1|1 | 0.0366 | 2.00 | DNAJC7 | Splice Region | ↑ |
| 17:45451894:G:A | rs4968318 | 1|1 | 0.0322 | 2.00 | EFCAB13 | Missense | ↑ |
| 3:85151828:T:G | rs13061527 | 0|1 | -0.0600 | 1.00 | CADM2 | Intronic | ↓ |
| 9:107680458:C:T | rs2437811 | 1/1 | -0.0299 | 2.00 | ABCA1 | Intronic | ↓ |
| 15:31369123:A:G | rs4779816 | 1|1 | -0.0293 | 2.00 | TRPM1 | Loss of Function | ↓ |
Cataracts are a clouding of the eye's natural lens that leads to blurry vision and glare sensitivity. They are the most common cause of reversible vision loss and typically develop gradually with age. UV exposure, diabetes, and genetics all influence risk.
Your score for Cataract is near the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 15:28356859:C:T | rs1129038 | 1/1 | -0.0297 | 2.00 | HERC2 | 3-prime UTR | ↓ |
| 1:10824329:T:C | rs6540950 | 1|1 | -0.0293 | 2.00 | CASZ1 | Intronic | ↓ |
| 20:10701594:G:T | rs6040107 | 1/1 | -0.0274 | 2.00 | RP11-103J8.1 | Intronic | ↓ |
| 20:19477390:A:G | rs6046144 | 0|1 | 0.0530 | 1.00 | SLC24A3 | Intronic | ↑ |
| 17:54703475:C:T | rs4794653 | 1|1 | 0.0190 | 2.00 | — | Intergenic | ↑ |
| 9:22347178:C:A | rs2025795 | 1|1 | 0.0177 | 2.00 | — | Intergenic | ↑ |
| 1:227195728:C:T | rs1929863 | 1|0 | 0.0308 | 1.00 | CDC42BPA | Intronic | ↑ |
| 11:30848413:C:T | rs1448941 | 1|1 | -0.0152 | 2.00 | DCDC1 | Downstream | ↓ |
| 9:22098574:A:G | rs4977574 | 0/1 | 0.0296 | 1.00 | CDKN2B-AS1 | Intronic | ↑ |
| 1:198869514:T:C | rs10800598 | 1|1 | -0.0145 | 2.00 | MIR181A1HG | Non-coding | ↓ |
Chronotype describes your body's natural preference for when to sleep and wake. "Morning larks" feel most alert early in the day, while "night owls" peak later. This is strongly influenced by genetics and shifts across the lifespan.
Your score for Chronotype falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (3.19). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 1:182569626:T:C | rs1144566 | 1|1 | 0.0507 | 2.00 | RGS16 | Missense | ↑ |
| 6:55142337:A:G | rs2653349 | 1/1 | 0.0194 | 2.00 | HCRTR2 | Missense | ↑ |
| 2:77213103:C:T | rs7563917 | 1|1 | 0.0156 | 2.00 | AC079117.1 | Non-coding | ↑ |
| 7:96468009:G:A | rs10254255 | 1|1 | -0.0139 | 2.00 | — | Intergenic | ↓ |
| 18:38026570:T:C | rs4799549 | 1|1 | 0.0112 | 2.00 | — | Intergenic | ↑ |
| 17:8108331:A:G | rs1059476 | 1|1 | 0.0108 | 2.00 | AURKB | Missense | ↑ |
| 2:239306268:A:C | rs3739070 | 0/1 | 0.0199 | 1.00 | TRAF3IP1 | Missense | ↑ |
| 7:24081855:A:G | rs10234716 | 1|1 | 0.0099 | 2.00 | — | Intergenic | ↑ |
| 3:185990096:C:T | rs2193587 | 1|1 | 0.0098 | 2.00 | DGKG | Missense | ↑ |
| 22:40554008:T:G | rs6001807 | 1|1 | 0.0095 | 2.00 | TNRC6B | Intronic | ↑ |
How much coffee you drink is partly genetic. Variants in genes that affect caffeine metabolism (like CYP1A2) and caffeine sensitivity influence whether you crave multiple cups a day or find even one too stimulating.
Your score for Coffee intake falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (3.33 cups per day). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 7:17284577:T:C | rs4410790 | 1/1 | 0.1128 | 2.00 | — | Intergenic | ↑ |
| 7:17430004:C:A | rs7777586 | 1|1 | -0.0325 | 2.00 | AC019117.1 | Intronic | ↓ |
| 2:634905:T:C | rs6548238 | 1/1 | 0.0268 | 2.00 | — | Regulatory | ↑ |
| 4:89052323:G:T | rs2231142 | 0/1 | -0.0393 | 1.00 | ABCG2 | Missense | ↓ |
| 18:57851763:A:G | rs10871777 | 0/1 | 0.0361 | 1.00 | — | Intergenic | ↑ |
| 1:49910568:G:A | rs1167268 | 1|1 | -0.0167 | 2.00 | AGBL4-IT1 | Intronic | ↓ |
| 17:18775900:A:G | rs4393623 | 1|1 | 0.0149 | 2.00 | PRPSAP2 | Missense | ↑ |
| 2:27730940:T:C | rs1260326 | 1/0 | 0.0295 | 1.00 | GCKR | Missense | ↑ |
| 12:11338781:C:A | rs1669413 | 1/1 | -0.0137 | 2.00 | TAS2R42 | Missense | ↓ |
| 21:30594334:T:C | rs2832268 | 1|1 | 0.0129 | 2.00 | BACH1 | Intronic | ↑ |
Sleep duration is partly heritable and varies naturally between individuals. Genes influencing circadian rhythm and sleep-wake signaling contribute to whether you tend to need more or less sleep each night.
Your score for Sleep duration falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (8.20 hours). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 2:114090412:A:G | rs1823125 | 0/1 | 0.0338 | 1.00 | — | Intergenic | ↑ |
| 1:34743076:T:G | rs1342153 | 1|1 | -0.0086 | 2.00 | RP4-657M3.2 | Upstream | ↓ |
| 14:26974414:A:C | rs178189 | 1|1 | 0.0082 | 2.00 | NOVA1 | Intronic | ↑ |
| 5:135620850:T:C | rs1499767 | 1|1 | -0.0079 | 2.00 | TRPC7 | Intronic | ↓ |
| 1:65250982:T:G | rs2483616 | 1|1 | 0.0075 | 2.00 | RAVER2 | Intronic | ↑ |
| 16:78420775:G:A | rs11545029 | 1|1 | -0.0074 | 2.00 | WWOX | Missense | ↓ |
| 10:70332580:A:G | rs10823229 | 1|1 | -0.0070 | 2.00 | TET1 | Missense | ↓ |
| 10:125003630:T:C | rs7089041 | 1|1 | -0.0067 | 2.00 | — | Intergenic | ↓ |
| 17:4764359:C:T | rs8073970 | 1|1 | -0.0064 | 2.00 | MINK1 | Intronic | ↓ |
| 1:31687774:T:C | rs6671739 | 1|1 | 0.0063 | 2.00 | NKAIN1 | Intronic | ↑ |
Genes involved in alcohol metabolism and reward pathways can influence how frequently a person drinks. Variants in enzymes like ADH and ALDH affect how your body processes alcohol and how it makes you feel.
Your score for Alcohol intake frequency falls somewhat below the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (4.84 categories). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 4:100239319:T:C | rs1229984 | 1|1 | 0.2145 | 2.00 | ADH1B | Missense | ↑ |
| 2:27730940:T:C | rs1260326 | 1/0 | 0.0336 | 1.00 | GCKR | Missense | ↑ |
| 4:184831715:A:G | rs2278475 | 1|1 | -0.0130 | 2.00 | STOX2 | Intronic | ↓ |
| 4:172552376:G:A | rs1027206 | 1|1 | -0.0120 | 2.00 | RP11-97E7.2 | Intronic | ↓ |
| 11:121801129:T:C | rs1666658 | 1|1 | -0.0117 | 2.00 | — | Regulatory | ↓ |
| 3:49924940:T:C | rs1062633 | 1|1 | -0.0115 | 2.00 | MST1R | Missense | ↓ |
| 10:99713117:T:C | rs533358 | 1|1 | -0.0113 | 2.00 | CRTAC1 | Intronic | ↓ |
| 12:54660427:G:A | rs57281063 | 0|1 | 0.0221 | 1.00 | RP11-968A15.2 | Intronic | ↑ |
| 6:17173376:G:A | rs2181349 | 1|1 | 0.0109 | 2.00 | — | Intergenic | ↑ |
| 10:133978962:T:C | rs2172131 | 1|1 | 0.0098 | 2.00 | JAKMIP3 | Intronic | ↑ |
Genetics can influence traits like nicotine sensitivity and reward-seeking behavior that affect the likelihood of taking up smoking. Environmental and social factors also play a major role.
Your score for Non-smoking likelihood is above the population average, suggesting a higher-than-average predisposition.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 2:146125523:C:T | rs10427255 | 1/1 | 0.0213 | 2.00 | — | Intergenic | ↑ |
| 5:166992708:C:T | rs11747772 | 1|1 | 0.0190 | 2.00 | TENM2 | Intronic | ↑ |
| 14:29469373:T:C | rs10148671 | 1/1 | -0.0179 | 2.00 | RP11-148E17.1 | Intronic | ↓ |
| 5:173279842:C:T | rs359457 | 1/1 | 0.0178 | 2.00 | — | Intergenic | ↑ |
| 20:14860884:G:A | rs6042960 | 1|1 | 0.0167 | 2.00 | MACROD2 | Intronic | ↑ |
| 11:4661285:A:G | rs905871 | 1|1 | 0.0166 | 2.00 | OR51D1 | Missense | ↑ |
| 4:159601676:C:T | rs11559290 | 1/1 | -0.0165 | 2.00 | ETFDH | Missense | ↓ |
| 2:226273689:T:C | rs2048936 | 1|1 | -0.0161 | 2.00 | NYAP2 | Synonymous | ↓ |
| 3:17892481:A:G | rs6577599 | 1|1 | -0.0159 | 2.00 | TBC1D5 | Intronic | ↓ |
| 2:614168:A:G | rs2947411 | 1/1 | -0.0159 | 2.00 | — | Intergenic | ↓ |
How old you look relative to your actual age is partly genetic. Genes involved in skin elasticity, pigmentation, and cellular repair processes influence the rate of facial aging. Sun exposure, smoking, and lifestyle also play major roles.
Your score for Facial aging is near the population average.
Odds ratio across PRS percentile bins
Odds ratio per PRS decile vs. population average (OR = 1.0, dashed). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 8:130699140:T:C | rs10956486 | 1|0 | 0.0727 | 1.00 | RP11-419K12.1 | Upstream | ↑ |
| 9:16864521:C:T | rs2153271 | 1/1 | -0.0346 | 2.00 | BNC2 | Intronic | ↓ |
| 2:145634153:G:A | rs6738560 | 1|1 | 0.0323 | 2.00 | TEX41 | Intronic | ↑ |
| 9:205964:A:G | rs478882 | 1/1 | -0.0307 | 2.00 | — | Intergenic | ↓ |
| 20:39832628:T:C | rs17265513 | 1/1 | 0.0234 | 2.00 | ZHX3 | Missense | ↑ |
| 2:56040099:T:C | rs10199082 | 1|0 | -0.0463 | 1.00 | — | Intergenic | ↓ |
| 2:219903258:T:G | rs6736922 | 1|1 | 0.0215 | 2.00 | CCDC108 | Loss of Function | ↑ |
| 6:151579432:C:T | rs4869723 | 0|1 | 0.0374 | 1.00 | AKAP12 | Intronic | ↑ |
| 1:201314624:A:G | rs2153715 | 1|1 | -0.0177 | 2.00 | — | Intergenic | ↓ |
| 5:92666066:G:T | rs6863143 | 1|1 | 0.0168 | 2.00 | — | Intergenic | ↑ |
Walking pace is a surprisingly strong predictor of overall health and longevity. It reflects cardiovascular fitness, musculoskeletal health, and neurological function. Genetics influence the traits that contribute to walking speed, including muscle composition and body proportions.
Your score for Walking pace is near the population average.
Effect size across PRS percentile bins
Effect size per PRS decile, reference line at population mean (3.32 meters/second). Error bars: 95% CI. Source: Tanigawa et al. (2023).
Top contributing variants (10)
| Variant | rsID | Genotype | Effect Weight | Dosage | Gene | Type | |
|---|---|---|---|---|---|---|---|
| 3:49936102:T:C | rs2230590 | 1/1 | -0.0054 | 2.00 | MST1R | Missense | ↓ |
| 3:184039666:A:G | rs2178403 | 1|1 | 0.0043 | 2.00 | EIF4G1 | Missense | ↑ |
| 7:113605108:T:C | rs12705924 | 1|1 | 0.0042 | 2.00 | PPP1R3A | Intronic | ↑ |
| 18:53210302:G:T | rs613872 | 0/1 | -0.0083 | 1.00 | TCF4 | Intronic | ↓ |
| 4:182733332:T:C | rs4862006 | 1|1 | 0.0041 | 2.00 | — | Intergenic | ↑ |
| 2:41199040:G:A | rs1981804 | 1|1 | 0.0041 | 2.00 | — | Intergenic | ↑ |
| 1:25015638:C:T | rs7511698 | 1|1 | 0.0037 | 2.00 | — | Regulatory | ↑ |
| 6:137760308:C:T | rs9321606 | 1|1 | 0.0036 | 2.00 | — | Intergenic | ↑ |
| 18:37426101:C:A | rs56759062 | 1|1 | -0.0036 | 2.00 | RP11-636O21.1 | Intronic | ↓ |
| 3:88189341:T:C | rs7653652 | 1|1 | -0.0036 | 2.00 | ZNF654 | Missense | ↓ |
The following trait(s) could not be included because the scoring file had insufficient overlap with your genotype data (less than 50% of variants matched).
- Ankylosing spondylitis (PGS001267)
Important Disclaimers
Key Genetic Variants
The Key Genetic Variants section screens for individual high-penetrance variants in genes linked to specific health conditions. Unlike polygenic risk scores, a single variant can significantly increase risk for a condition. Carrier status indicates you carry one or more copies of a risk allele but does not mean you will develop the condition. Penetrance varies by variant. Consult a genetic counselor for clinical interpretation.
What is a Polygenic Risk Score?
A polygenic risk score aggregates the effect of many genetic variants into a single number reflecting genetic predisposition for a trait. Higher scores generally indicate greater genetic predisposition, but genetics is only one factor. Lifestyle, environment, and medical history all play important roles. A high PRS does not mean you will develop a condition.
Percentile & Odds Ratio Estimates
Percentile values are estimated against a reference population of PGP participants matched to your inferred ancestry. Odds ratios reflect relative risk compared to the middle decile of the reference population. These are statistical estimates and exact numbers carry uncertainty. They should not be interpreted as precise personal risk predictions.
Ancestry Limitation
All polygenic scores in this report were trained on European-ancestry data from the UK Biobank (predominantly white British participants). Percentile estimates are calibrated against a European-ancestry PGP reference population (n=119). For individuals of non-European ancestry, scores, percentiles, and risk estimates are likely to be less accurate and may not reflect true genetic predisposition. The odds ratio bins from Tanigawa et al. were also derived from the same European-ancestry cohort. Use this report with extra caution if you are not of European ancestry.
Not a Clinical Test
This report is for research and educational purposes only. It is not a clinical diagnostic test. Consult a healthcare provider or genetic counselor before making any health decisions based on this information.
Methodology
Input processing: Raw consumer genotyping data is normalized into a standardized variant format and aligned to the GRCh37 (hg19) human reference genome. Quality checks are applied to filter low-confidence calls and ensure compatibility with downstream analysis.
Imputation: Consumer genotyping arrays typically capture 600,000–700,000 variants. To fill in the millions of variants not directly measured, we perform genome-wide statistical imputation using a large, ethnically diverse reference panel. This process infers likely genotypes at untyped positions based on patterns of linkage disequilibrium observed in reference populations, expanding coverage to approximately 30 million variants across all 22 autosomes. Whole-genome sequencing (WGS) data already covers the full genome and does not require imputation.
Ancestry inference: Your genetic ancestry is estimated by comparing your genotype profile to reference populations spanning five major continental superpopulations (European, African, East Asian, South Asian, and Admixed American). A machine learning classifier trained on thousands of reference samples assigns the most likely ancestry group, which is used to select the appropriate reference distribution for percentile estimation.
Polygenic risk score calculation: Polygenic risk scores are computed by combining the effects of many genetic variants, each weighted according to its published association with a given trait. Scoring weights are sourced from the PGS Catalog, an open database of published polygenic scores. Each variant in your imputed genotype data is matched against the scoring file and the weighted sum is calculated to produce a single composite score per trait.
Percentile and risk estimation: Your raw score for each trait is compared against an empirical reference distribution to determine your percentile ranking. Relative risk (odds ratios) are estimated by mapping your score to population-level decile bins derived from large-scale biobank research. These estimates are stratified by inferred genetic ancestry to improve accuracy.
Frequently Asked Questions
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My report says I have a higher genetic tendency for a trait, but that doesn't match me at all. Why?Polygenic risk scores capture genetic predisposition, not destiny. Many traits are shaped by a combination of genetics, environment, lifestyle, diet, and chance. A high score means your DNA nudges you in that direction compared to average, but plenty of people with high scores never develop a condition and vice versa. Think of it as one piece of a larger puzzle.
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Does a high risk score mean I'm going to get a disease?No. A higher score means you may have a greater genetic predisposition, but it is not a diagnosis or a guarantee. Most common diseases are influenced by many factors beyond genetics, including age, lifestyle, family history, and preventive care. Many people with elevated scores never develop the condition.
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Should I change my medication or start new treatment based on this report?No. This report is for educational and informational purposes only. It is not a clinical test and should never replace advice from a healthcare provider. Do not start, stop, or change any medication based on these results. If something in this report concerns you, bring it to your doctor or a genetic counselor for a proper clinical evaluation.
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Why doesn't my height / BMI / blood pressure match the score?For continuous traits like height or blood pressure, the score reflects your genetic tendency — not a measurement of your actual value. Your real-world measurement is the result of genetics plus everything else: nutrition, exercise, medications, aging, and more. It is completely normal for your actual measurement to differ from what your genetics alone would predict.
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What does "percentile" mean in this report?Your percentile tells you where your score falls compared to a reference population. For example, a 75th percentile means your genetic score is higher than approximately 75% of people in the reference group. It does not mean you have a 75% chance of anything — it is a ranking, not a probability.
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Are these results accurate for all ethnicities?The scores in this report were developed using data primarily from people of European ancestry (UK Biobank). They may be less accurate for individuals of other ancestral backgrounds. Polygenic scores generally transfer less well across populations due to differences in allele frequencies and linkage patterns. We display your inferred ancestry at the top of the report for transparency.
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Can I share this report with my doctor?Yes, you are welcome to share this report with your healthcare provider. It can serve as a conversation starter about your genetic background. However, your doctor will likely want to consider your full medical history, family history, and possibly order clinical-grade genetic testing before making any medical decisions.
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Why are some traits missing from my report?A trait may be excluded if too few of its required genetic variants were found in your data after imputation. Each score requires a minimum overlap with the published variant list to produce reliable results. Excluded traits (if any) are listed near the bottom of the report.
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How is this different from a clinical genetic test?Clinical genetic tests are performed in certified laboratories under strict quality controls (such as CLIA/CAP accreditation) and are interpreted by trained geneticists. This report uses consumer genotyping data and publicly available risk scores for research and educational purposes. It has not been validated for clinical decision-making.
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Will my scores change if I get re-tested?Your DNA does not change, so the raw genetic data would be the same. However, scores could shift slightly if the analysis uses an updated scoring model, different imputation panel, or a larger reference population. The underlying science of polygenic scores is still evolving, and newer models may give somewhat different estimates.