Lymphocytes are a type of white blood cell central to the adaptive immune system, including T cells and B cells. They are responsible for recognizing and remembering specific pathogens, producing antibodies, and killing infected cells. Lymphocyte count is an important indicator of immune system function.
Score Details
This score comes from the PGS Catalog, an open repository of published polygenic scoring models used in genomic research.
- PGS ID
- PGS001199
- Score Name
- GBE_INI30120
- Reported Trait
- Lymphocyte count
- Development Method
- snpnet
- Number of Variants
- 4,212
- Original Genome Build
- GRCh37
- Weight Type
- NR
- Release Date
- October 21, 2021
Source Publication
Significant sparse polygenic risk scores across 813 traits in UK Biobank.
Development Samples
Polygenic risk scores are developed against large reference datasets. This score was built using the UK Biobank, a biomedical cohort with genetic and health data from roughly 500,000 participants — large enough to identify reliable genetic associations.
| Ancestry | Sample Size | Country | Cohort |
|---|---|---|---|
| European(white British ancestry) | 261,890 | UK | UKB |
Ancestry Distribution
Development (261,890 individuals)
Evaluation (5 sample sets)
Performance Evaluations
Polygenic risk scores are usually developed and validated in populations of European ancestry. Predictive accuracy can vary across ancestries because of differences in genetic architecture, linkage disequilibrium patterns, and allele frequencies. For quantitative traits, R² is the proportion of variance in the trait explained by the score. Values substantially below the best-performing ancestry are highlighted to flag reduced transferability.
| AncestryThe broad ancestral population of the evaluation sample. | NNumber of individuals in the evaluation sample. | R²Proportion of variance explained by the full model (PGS + covariates). Higher is better. | PGS R²Proportion of variance explained by the PGS alone, without covariates. Isolates the predictive power of the genetic score. |
|---|---|---|---|
| African | 6,120 | 0.0151[0.0092, 0.0210] | 0.0066[0.0026, 0.0105] |
| East Asian | 1,654 | 0.0775[0.0532, 0.1018] | 0.0308[0.0147, 0.0469] |
| European | 24,129 | 0.0405[0.0357, 0.0453] | 0.0350[0.0305, 0.0395] |
| South Asian | 7,491 | 0.0404[0.0319, 0.0490] | 0.0293[0.0219, 0.0366] |
| European | 65,520 | 0.0257[0.0233, 0.0280] | 0.0207[0.0186, 0.0228] |
Covariates: age, sex, UKB array type, Genotype PCs
Downloads & Links
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