Polygenic Risk Score Reports, Compared
Polygenic risk scores have gone mainstream, and the consumer genomics market has fragmented into subscription platforms, WGS-bundled reports, and a handful of one-time upload services. Here's a neutral side-by-side of the options people actually consider in 2026.
At a glance
You already have a DNA file and want a focused, one-time polygenic risk score report with 71 scores for $49.
You want bundled WGS (Nucleus), ongoing coaching + supplement recs (SelfDecode), or an FDA-regulated brand (23andMe+).
Pricing
Public list prices. Genomisaur Family Full is currently $49.5 with code LAUNCH50.
| Option | Price | What it is |
|---|---|---|
| Genomisaur — Full Health Report | $49 one-time | 71 PRS + trait predictions from existing DNA |
| Nucleus Genomics | $399 + $39/yr | WGS-bundled PRS + hundreds of conditions |
| SelfDecode | ~$120/yr | Subscription with AI coaching + supplements |
| 23andMe+ Premium | $199 + $69/yr | Genotype kit + FDA-cleared health reports |
| Promethease | $12 per file | SNPedia variant lookup (not modern PRS) |
| Sequencing.com | Free upload; apps $5–$99 each | App marketplace, 300+ report apps |
Competitor prices sourced from Public list price on mynucleus.com as of 2026. Update periodically; confirm on the vendor's site before purchasing.
Feature comparison
Side-by-side on the things that actually change what the product does for you.
| Feature | Genomisaur | Consumer PRS market | Edge |
|---|---|---|---|
| Accepts 23andMe / AncestryDNA / MyHeritage | Yes | SelfDecode, 23andMe, Promethease, Sequencing.com: yes. Nucleus: no. | |
| Payment model | One-time | Mostly subscription or kit+subscription | |
| Number of PRS | 71 across 14 categories | Nucleus ~20. SelfDecode dozens. 23andMe single-variant. | |
| Per-score methodology transparency | GWAS source + performance metrics on every card | Varies widely; often not disclosed | |
| Turnaround | ~20 min | Nucleus ~6 wk. 23andMe 3–5 wk. Others variable. | |
| Requires new kit | No | Nucleus + 23andMe: yes. Upload services: no. | |
| Cost over 3 years | $49 | Nucleus 477, SelfDecode 360, 23andMe+ 406 |
What each one does well
Genomisaur
- $49 one-time — cheapest polygenic risk score report in the market
- Largest PRS library in the upload category (71 scores, 14 categories)
- No subscription, no kit, no upsell — one report, yours to keep
- Every score cites its source GWAS and performance metrics
Consumer PRS market
- Nucleus: bundles WGS, best if you have no DNA data yet
- SelfDecode: richest ongoing experience with AI coaching + supplement recs
- 23andMe+: FDA-cleared reports and regulated brand
- Sequencing.com: broadest a-la-carte app marketplace
For most people with existing consumer DNA data, Genomisaur has the best price-to-coverage ratio in this market: 71 polygenic risk scores for $49, no subscription. If you have no DNA data yet, Nucleus Genomics is the cleanest one-stop WGS + PRS buy. If you want ongoing coaching and don't mind paying yearly, SelfDecode is the richer experience. Pick by what you actually need; we have tried to be straight about where each one is strong.
Frequently asked questions
What is a polygenic risk score, in one sentence?
A polygenic risk score sums the effects of many common genetic variants into a single number representing where a person sits on the population risk spectrum for a given trait or disease.
Which service has the most polygenic risk scores?
Of upload-friendly consumer services in 2026, Genomisaur publishes the most at 71 PRS across 14 categories. Nucleus and SelfDecode offer fewer (though Nucleus supplements its PRS with hundreds of single-gene condition reports).
Which is the cheapest?
Promethease at $12 is cheapest but is a single-SNP SNPedia lookup, not modern PRS. Among actual PRS reports, Genomisaur at $49 one-time is the cheapest.
Do any of these replace a doctor?
No. All consumer PRS reports — including Genomisaur — are informational. Discuss results with a qualified healthcare provider before making medical decisions.
Can I use more than one of these services?
Yes. A common stack: upload to Genomisaur for the fast $49 PRS readout; use Sequencing.com or SelfDecode for niche apps; add Nucleus WGS if you want rare-variant depth.
Informational, not diagnostic
Consumer preconception reports — ours, Consumer PRS market's, and others — are informational. Carrier and polygenic risk results should be discussed with a qualified healthcare provider or genetic counselor before making medical or reproductive decisions.