Preconception Genetic Reports, Compared
Preconception genetic testing has fragmented into products with very different goals: PGT-P on embryos (Orchid), WGS-backed single-person reports (Nucleus Preview), and bring-your-own-data two-parent analysis (Genomisaur). Which one fits depends mostly on where you are in the process and what data you already have.
At a glance
Couples planning a family, both with existing genetic data (or willing to upload a WGS VCF), who want polygenic risk + carrier screening + simulated offspring outcomes for $99 total.
Other buyers: Nucleus Preview if you need WGS bundled; Orchid if you are doing IVF and want actual embryo-level PGT-P screening.
Pricing
Public list prices. Genomisaur Family Full is currently $49.5 with code LAUNCH50.
| Option | Price | What it is |
|---|---|---|
| Genomisaur — Family Full | $99 (both parents) | Bring-your-own-DNA preconception report |
| Nucleus Preview | $399 per person | WGS-based single-person preconception report |
| Orchid — Couple Report | ~$1100 per couple | Whole-genome couple screening |
| Orchid — Embryo Report (PGT-P) | ~$2500 per embryo | Whole-genome screening of IVF embryos |
Competitor prices sourced from Public list price on mynucleus.com as of 2026. Update periodically; confirm on the vendor's site before purchasing.
Feature comparison
Side-by-side on the things that actually change what the product does for you.
| Feature | Genomisaur | Preconception market | Edge |
|---|---|---|---|
| Requires a new test? | No — bring your own data | Usually yes (WGS or embryo biopsy) | |
| Works for IVF / embryos? | No — pre-IVF / natural conception only | Orchid: yes. Nucleus: no. | |
| Two-parent simulated offspring? | Yes — 100 offspring | No | |
| Polygenic risk scores | 71 scores across 14 categories | Varies by vendor | |
| Carrier screening | CF, SCD, Tay-Sachs, SMA, and more | All vendors cover this | |
| Turnaround | ~2 hours | Weeks | |
| Price floor | $99 total | $399+ per person |
What each one does well
Genomisaur
- $99 for the full two-parent analysis
- Re-uses genetic data you already bought
- Only product that simulates 100 offspring genomes
- ~2 hour turnaround
Preconception market
- Orchid is the only product that actually screens IVF embryos (PGT-P)
- Nucleus Preview bundles whole genome sequencing, useful if you have no DNA data yet
- Both have more name recognition among IVF clinics
If your question is "can we see what our future children's genetic risk distribution looks like before we conceive?" — Genomisaur is the only product designed exactly for that at $99. If your question is "we are already doing IVF and want to screen embryos," use Orchid. If your question is "I want WGS for myself plus polygenic scores," use Nucleus Preview (or upload your Nucleus VCF to Genomisaur for $20 more).
Frequently asked questions
Do I need IVF to benefit from preconception genetic testing?
No. Genomisaur and Nucleus Preview both run on DNA from either parent without any medical procedure. IVF-specific screening (PGT-P) is only offered by Orchid and only if you are already doing IVF and want to screen actual embryos.
Which preconception report is cheapest?
Genomisaur Family Full at $99 covers both parents. Nucleus Preview is roughly $399 per person (~$798 per couple). Orchid is $1100+ per couple for the couple report and several thousand per embryo for PGT-P.
Can I use 23andMe data for preconception testing?
For Genomisaur, yes — both parents upload 23andMe, AncestryDNA, or MyHeritage raw-data files directly and we compute carrier screening and polygenic risk on top. Nucleus Preview does not accept consumer SNP array files; you need their own WGS or compatible VCFs.
What is the difference between carrier screening and a polygenic score?
Carrier screening looks for single high-impact variants in recessive disease genes (cystic fibrosis, sickle cell, Tay-Sachs, SMA). A polygenic risk score aggregates thousands of small-effect variants into a population-relative risk rank for a complex trait. A good preconception report includes both — Genomisaur Family Full, Nucleus Preview, and Orchid all do.
Is this a replacement for talking to a genetic counselor?
No. All preconception genetic reports — ours, Nucleus, and Orchid — are informational and should be discussed with a qualified clinician or genetic counselor before making reproductive decisions.
Informational, not diagnostic
Consumer preconception reports — ours, Preconception market's, and others — are informational. Carrier and polygenic risk results should be discussed with a qualified healthcare provider or genetic counselor before making medical or reproductive decisions.