A Nebula Genomics Alternative
Nebula Genomics shut down on February 5, 2025, leaving a lot of customers with a whole genome VCF file and nowhere to run reports on it. Here's what you can still do with a Nebula VCF, and the best alternatives if you want a polygenic risk score report in 2026.
At a glance
You have a Nebula Genomics VCF (or any WGS VCF) and want a polygenic risk score report on top of it for $69.
You need a replacement WGS provider and can wait weeks for a new sequencing run — Dante Labs or Nucleus Genomics are the active options.
Pricing
Public list prices. Genomisaur Family Full is currently $49.5 with code LAUNCH50.
| Option | Price | What it is |
|---|---|---|
| Genomisaur — Full Health Report (VCF upload) | $49 + $20 WGS fee | 71 PRS + trait predictions from your Nebula VCF |
| Nucleus Genomics (new WGS) | $399 + $39/yr | Fresh WGS + report platform |
| Dante Labs (new WGS) | ~$430 | Clinical 30× WGS + 200+ reports |
| Sequencing.com (VCF upload) | Free upload; apps $5–$99 each | App marketplace with 300+ report apps |
Competitor prices sourced from Public list price on mynucleus.com as of 2026. Update periodically; confirm on the vendor's site before purchasing.
Feature comparison
Side-by-side on the things that actually change what the product does for you.
| Feature | Genomisaur | Nebula Genomics | Edge |
|---|---|---|---|
| Accepts a Nebula VCF | Yes | Sequencing.com: yes. Nucleus: limited. Dante: no — they re-sequence. | |
| Need a new DNA sample? | No | Nucleus + Dante: yes | |
| Polygenic risk scores | 71 PRS across 14 categories | Varies | |
| Subscription required | No | Nucleus: $39/yr. Sequencing.com: per-app or subscription. | |
| Turnaround | ~20 min after upload | Weeks (re-sequencing) or variable |
What each one does well
Genomisaur
- Directly reads your existing Nebula VCF — no re-sequencing
- $69 total to get 71 PRS from your genome
- ~20 minute turnaround
- No subscription, no ongoing membership
Nebula Genomics
- If your Nebula data is corrupted or you want a fresh WGS run, Nucleus Genomics and Dante Labs are the active providers
- Sequencing.com has the widest app catalog if you like a la carte
If you still have your Nebula VCF, the cheapest path to a polygenic risk score report is uploading it to Genomisaur for $69. If you have lost access to your data or want a fresh whole genome run, Nucleus Genomics or Dante Labs are the leading active WGS providers — and you can then upload the new VCF to Genomisaur on top.
Frequently asked questions
Is Nebula Genomics coming back?
No. Nebula confirmed shutdown on February 5, 2025 and existing customers received a final data export window. If you downloaded your VCF, it remains usable elsewhere indefinitely.
Can Genomisaur read my Nebula VCF?
Yes. Genomisaur accepts .vcf and .vcf.gz files (both GRCh38 and hg19) from any whole genome sequencing provider, including the files Nebula customers kept after the shutdown. VCFs are processed for $20 on top of the standard report price.
What if I lost my Nebula VCF?
Without the file you need a new sequencing run. Nucleus Genomics ($399 + $39/yr) and Dante Labs (~$430) are the leading active WGS providers in 2026. Once you have the new VCF, you can upload it to Genomisaur for a 71-score polygenic risk report.
What other Nebula alternatives exist for uploading?
Sequencing.com accepts Nebula VCFs and runs them through its app marketplace. SelfDecode accepts SNP-array uploads but not always raw VCFs. Genomisaur is the most direct path if you want a focused PRS report from WGS data.
Informational, not diagnostic
Consumer preconception reports — ours, Nebula Genomics's, and others — are informational. Carrier and polygenic risk results should be discussed with a qualified healthcare provider or genetic counselor before making medical or reproductive decisions.