Promethease vs Genomisaur
Promethease is the classic budget option for turning a DNA file into a report — $12 gets you a SNPedia-powered literature dump. Genomisaur is a modern polygenic risk score report for $49. Both accept 23andMe, AncestryDNA, and MyHeritage uploads. They produce very different outputs.
At a glance
You want modern polygenic risk scores — probability-weighted aggregates of many variants — presented in a readable, categorized report.
You want the cheapest possible option and are comfortable reading a dense SNP-by-SNP literature dump powered by SNPedia.
Pricing
Public list prices. Genomisaur Family Full is currently $49.5 with code LAUNCH50.
| Option | Price | What it is |
|---|---|---|
| Genomisaur — Full Health Report | $49 one-time | 71 PRS + trait predictions |
| Promethease report | $12 per file | SNPedia-sourced variant-by-variant lookups |
| Additional files | $49 covers one person | +$4 per additional file |
Competitor prices sourced from Public list price on mynucleus.com as of 2026. Update periodically; confirm on the vendor's site before purchasing.
Feature comparison
Side-by-side on the things that actually change what the product does for you.
| Feature | Genomisaur | Promethease | Edge |
|---|---|---|---|
| Methodology | Multi-variant polygenic risk scores from modern GWAS | Single-SNP lookups against SNPedia | |
| Number of health conditions covered | 71 PRS across 14 categories | Thousands of SNP entries; quality varies | |
| Readability | Categorized cards with percentiles and source studies | Dense list of SNPs with wiki snippets | |
| Trait predictions | Yes — appearance, lifestyle | Available but raw-form | |
| Accepts 23andMe / AncestryDNA / MyHeritage | Yes | Yes | |
| Price | $49 | $12 | |
| Actively developed | Yes | Yes, under MyHeritage ownership |
What each one does well
Genomisaur
- Modern polygenic risk scoring, not 2012-era single-SNP lookups
- Categorized, readable report — not a wall of wiki snippets
- Per-score performance metrics and source GWAS
- Includes trait predictions and lifestyle genetics
Promethease
- Cheapest option at $12
- Very broad SNPedia coverage including rare variants
- Good for users who want to look up a specific SNP
If you want a useful consumer-grade health report, Genomisaur at $49 is the better purchase — single-SNP lookups are the wrong methodology for most common conditions, and most users find Promethease output hard to act on. If you are explicitly looking up named variants for research purposes and want a $12 literature dump, Promethease still does that job.
Frequently asked questions
Is Promethease still available in 2026?
Yes. Promethease is operated by MyHeritage and continues to sell $12 SNPedia-based reports. The methodology and interface have not changed meaningfully in years.
Why is Promethease so much cheaper?
Promethease is a one-shot lookup tool over the SNPedia wiki — it runs an automated query, not a curated polygenic analysis. Genomisaur's PRS pipeline, performance validation, and per-score GWAS curation are the work you're paying for.
Is single-SNP analysis useful at all?
For a handful of well-characterized high-impact variants (BRCA, APOE, a few pharmacogenomic markers), yes. For most common diseases, single-SNP lookups are misleading because risk is polygenic — spread across thousands of small-effect variants. That is exactly what PRS is designed for.
Can I use both?
Yes. Some users run Promethease for its breadth and Genomisaur for its curated polygenic output. If you had to pick one for a real health readout, we'd recommend PRS.
Informational, not diagnostic
Consumer preconception reports — ours, Promethease's, and others — are informational. Carrier and polygenic risk results should be discussed with a qualified healthcare provider or genetic counselor before making medical or reproductive decisions.